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The Macrophage: A New Factor in UVR-Induced Melanomagenesis.
MedLine Citation:
PMID:  23760048     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
UVR is one of the major risk factors for melanoma development. However, the mechanisms by which UVR leads to the development of melanoma are not fully understood. Handoko et al. (this issue) explicitly indicate that macrophages are essential for UVR-induced melanocyte proliferation and migration using a neonatal mouse model. Although the functions and mechanisms of macrophages on melanoma development must be investigated further, the link between macrophages and melanocyte responses is striking, suggesting that macrophages might be a target for preventing UVR-induced melanoma.
Authors:
Tao Wang; Meenhard Herlyn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  133     ISSN:  1523-1747     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1711-3     Citation Subset:  IM    
Affiliation:
Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania, USA.
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