Document Detail

Macrophage Migration Inhibitory Factor in Myocardial Ischemia/Reperfusion Injury.
MedLine Citation:
PMID:  24675723     Owner:  NLM     Status:  Publisher    
Acute myocardial infarction (AMI) remains one of the leading causes of death in the developed world. There is emerging evidence that the cytokine macrophage migration inhibitory factor (MIF) is a crucial player in AMI. Cardioprotection by MIF is likely to be a multifactorial phenomenon mediated by receptor-mediated signaling processes, intracellular protein-protein interactions, and enzymatic redox-regulation. Coordinating several pathways in the ischemic heart, MIF contributes to receptor-mediated regulation of cardioprotective AMP-activated protein kinase signaling, inhibition of pro-apoptotic cascades and the reduction of oxidative stress in the post-ischemic heart. Moreover, the cardioprotective properties of MIF are modulated by S-nitros(yl)ation. These effects in the pathophysiology of myocardial I/R injury qualify MIF as a promising therapeutic target in the future. We here summarize the findings of experimental and clinical studies and highlight the therapeutic potential of MIF in AMI.
Tienush Rassaf; Christian Weber; Jürgen Bernhagen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-27
Journal Detail:
Title:  Cardiovascular research     Volume:  -     ISSN:  1755-3245     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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