| Macrophage Migration Inhibitory Factor Isolated from a Parasite Inhibited Th2 Cytokine Production in PBMCs of Atopic Asthma Patients. | |
| | |
MedLine Citation:
|
PMID: 22149098 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background. In a previous study, we demonstrated that the human macrophage migration inhibitory factor (MIF)-like protein (As-MIF) isolated from helminths could inhibit allergic airway inflammation via the recruitment of CD4(+)CD25(+)Foxp3(+) T cells. Objective. To evaluate the clinical importance of As-MIF as an antiasthma drug, we evaluated immune responses after recombinant As-MIF (rAs-MIF) treatment in peripheral blood mononuclear cell (PBMC) cultures. Methods. PBMC was isolated from 10 patients with atopic asthma, 8 patients with nonatopic asthma, and 12 nonatopic healthy subjects, and various concentrations of rAs-MIF were transferred into the PBMC culture medium. After 3 days, we measured the levels of T helper 2 and T helper 1 cytokines via ELISA. Results. In atopic asthma, IL-4 and IL-5 production was significantly reduced in the PBMC cultures after rAs-MIF treatment. These inhibitory effects were not observed in the nonatopic asthma group. By way of contrast, IL-10 production in the PMBC cultures was significantly increased after rAs-MIF treatment in all experimental groups. Conclusion. The results of this study are similar to those previously reported in a mouse study, suggesting that As-MIF might be a candidate for the specific treatment of asthma. |
| | |
Authors:
|
Hye-Kyung Paark; Min Kyoung Cho; Hee Young Park; Ki Uk Kim; Yun Seong Kim; Min Ki Lee; Soon Kew Park; Dong-Hee Kim; Hak Sun Yu |
Related Documents
:
|
19232438 - An immune deficiency homolog from the white shrimp, litopenaeus vannamei, activates ant... 16715068 - Is rna interference involved in intrinsic antiviral immunity in mammals? 20697548 - Innate immunity in the adult mammalian heart: for whom the cell tolls. 21810608 - A strain of lactobacillus casei inhibits the effector phase of immune inflammation. 18922918 - Balancing between antitumor efficacy and autoimmune pathology in t-cell-mediated target... 22577258 - Pentraxin 3(ptx 3): an endogenous modulator of the inflammatory response. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-7 |
Journal Detail:
|
Title: The Journal of asthma : official journal of the Association for the Care of Asthma Volume: - ISSN: 1532-4303 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8106454 Medline TA: J Asthma Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Internal Medicine, School of Medicine, Pusan National University , Busan, Republic of Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cytocompatible Encapsulation of Individual Chlorella Cells within Titanium Dioxide Shells by a Des...
Next Document: Human ?-Defensins and Psoriasin/S100A7 Expression in Salivary Glands: Anti-Oncogenic Molecules for P...