Document Detail


Macrophage differentiation and function in atherosclerosis: opportunities for therapeutic intervention?
MedLine Citation:
PMID:  22572544     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The macrophage is exquisitely sensitive to its microenvironment, as demonstrated primarily through in vitro study. Changes in macrophage phenotype and function within the atherosclerotic plaque have profound consequences for plaque biology, including rupture and arterial thrombosis leading to clinical events such as myocardial infarction. We review the evidence for dynamic changes in macrophage numbers and macrophage differentiation within the atherosclerotic plaque microenvironment and discuss potential approaches to target macrophage differentiation for therapeutic benefit in cardiovascular disease.
Authors:
Howell J Williams; Edward A Fisher; David R Greaves
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-04-27
Journal Detail:
Title:  Journal of innate immunity     Volume:  4     ISSN:  1662-8128     ISO Abbreviation:  J Innate Immun     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-05     Completed Date:  2013-01-14     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  101469471     Medline TA:  J Innate Immun     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  498-508     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Affiliation:
Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Atherosclerosis / immunology*,  physiopathology,  therapy*
Cell Differentiation*
Cytokines / metabolism
Humans
Macrophages / cytology*,  immunology*,  metabolism
Mice
Grant Support
ID/Acronym/Agency:
P01 HL098055/HL/NHLBI NIH HHS; P01 HL098055/HL/NHLBI NIH HHS; R01 HL084312/HL/NHLBI NIH HHS; R01 HL084312/HL/NHLBI NIH HHS; RG/10/15/28578//British Heart Foundation
Chemical
Reg. No./Substance:
0/Cytokines
Comments/Corrections

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