| Macrophage colony-stimulating factor (M-CSF) in plasma and CSF of patients with mild cognitive impairment and Alzheimer's disease. | |
| | |
MedLine Citation:
|
PMID: 20455868 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Macrophage colony-stimulating factor (M-CSF) is a hematopoietic growth factor that activates microglial cells, involved in phagocytosis of amyloid-beta (Abeta) in the brain. In the present study, we found in 50 patients with Alzheimer's disease (AD) significantly increased M-CSF plasma levels compared to 22 patients with mild cognitive impairment (MCI) and 35 age-matched healthy controls. In contrast, MCI patients showed significantly decreased M-CSF levels in cerebrospinal fluid (CSF) compared to AD patients and 20 patients with other non-inflammatory neurological disease (NIND). Analyzing the impact of Beta-amyloid 1-42 (Abeta 1-42), tau protein and M-CSF for differentiation between the groups we found that M-CSF, but not Abeta 1-42 and tau-protein is a significant parameter for distinction between MCI and NIND patients with 68.8% sensitivity and 75.0% specificity. M-CSF CSF levels < or = 357.8 pg/ml yielded 73.7% sensitivity and 75.0% specificity for diagnosing MCI patients in comparison with control subjects. In conclusion, our data indicate that M-CSF in CSF could be a putative biomarker for MCI. |
| | |
Authors:
|
C Laske; E Stransky; N Hoffmann; W Maetzler; G Straten; G W Eschweiler; T Leyhe |
Related Documents
:
|
655658 - Bilateral oculomotor paralysis due to neurosyphilis. 3612198 - Phagocytic activity of csf monocytes in neurological diseases. 3945178 - Molecular forms of cholinesterases in csf of alzheimer's disease/senile dementia of alz... 9618698 - Cisternal csf levels of cytokines after subarachnoid hemorrhage. 9692388 - Thrombopoietin level is inversely related to blast count, not platelet number, in down ... 14660288 - Reversal of fluoxetine-induced sexual dysfunction by switching to escitalopram. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Current Alzheimer research Volume: 7 ISSN: 1875-5828 ISO Abbreviation: Curr Alzheimer Res Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-08-02 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101208441 Medline TA: Curr Alzheimer Res Country: United Arab Emirates |
Other Details:
|
Languages: eng Pagination: 409-14 Citation Subset: IM |
Affiliation:
|
Department of Psychiatry and Psychotherapy, University of Tübingen, Osianderstr. 24, D-72076 Tübingen, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Established donepezil treatment modulates task relevant regional brain activation in early Alzheimer...
Next Document: Aortic arch calcification and mortality in chronic hemodialysis patients.