Document Detail

Macronutrients, aluminium from drinking water and foods, and other metals in cognitive decline and dementia.
MedLine Citation:
PMID:  17119295     Owner:  NLM     Status:  MEDLINE    
A possible role of the macronutrients and the basic elements of carbohydrates (glucose administration or depletion), proteins (amino acids such as tryptophan and tyrosine), and fat (unsaturated fatty acids) was recently proposed for age-related changes of cognitive function, and the cognitive decline of degenerative (AD) or vascular origin. The availability and utilization of glucose has been implicated in cognitive function not only as a result of nutritional and systemic metabolic conditions, but also, although speculatively, as a crucial phase of the mechanism of action of molecules used as cognitive-enhancers. Furthermore, many lines of evidence have focused on the importance of oxidative stress mechanisms and free radical damage in AD pathogenesis. In addition, epidemiological studies have recently reported an association between alcohol and the incidence of AD and predementia syndromes. Foods with large amounts of aluminium-containing additives or aluminium from drinking water may affect the risk of developing AD, aluminium more likely acting as a cofactor somewhere in the cascade of events leading to the demented brain. A role for other metals in dementia have been speculated, given the encouraging results reported from studies on peripheral zinc concentrations, zinc supplementation, serum copper, either bound with ceruloplasmin or not, and iron metabolism in AD. Nonetheless, more data are needed to support a possible role of these metals in dementing diseases. Healthy diets, antioxidant supplements, and the prevention of nutritional deficiencies or exposure to foods and water with high content of metals could be considered the first line of defence against the development and progression of cognitive decline.
Vincenzo Solfrizzi; Anna Maria Colacicco; Alessia D'Introno; Cristiano Capurso; Angelo Del Parigi; Sabrina A Capurso; Francesco Torres; Antonio Capurso; Francesco Panza
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of Alzheimer's disease : JAD     Volume:  10     ISSN:  1387-2877     ISO Abbreviation:  J. Alzheimers Dis.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-22     Completed Date:  2007-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9814863     Medline TA:  J Alzheimers Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  303-30     Citation Subset:  IM    
Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy.
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MeSH Terms
Aluminum / adverse effects*,  analysis*
Alzheimer Disease / diagnosis,  etiology
Cognition Disorders / diagnosis,  etiology*
Dementia / diagnosis,  etiology*
Food Contamination
Neuropsychological Tests
Oxidative Stress / physiology
Severity of Illness Index
Water / chemistry*
Reg. No./Substance:
0/Carbohydrates; 7429-90-5/Aluminum; 7732-18-5/Water

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