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Macromolecular metabolism in compensatory renal hypertrophy.
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MedLine Citation:
PMID:  366927     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The initial biochemical changes of compensatory hypertrophy occur well within 1 hour of unilateral nephrectomy and perhaps within the first few minutes.2. The initial increment in rRNA is from decreased metabolism rather than from increased synthesis.3. Changes in the processing of mRNA precursors are probably also important.4. Compensatory hypertrophy is regulated by a humoral stimulus or stimuli.5. The stimulus needs to be present virtually all of the time during the early phases of compensatory hypertrophy.6. The stimulus is related to loss of renal mass, not to loss of renal function.
Authors:
R A Malt
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The Yale journal of biology and medicine     Volume:  51     ISSN:  0044-0086     ISO Abbreviation:  Yale J Biol Med     Publication Date:    1978 May-Jun
Date Detail:
Created Date:  1979-03-24     Completed Date:  1979-03-24     Revised Date:  2012-05-30    
Medline Journal Info:
Nlm Unique ID:  0417414     Medline TA:  Yale J Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  419-28     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Animals
Blood
DNA / metabolism*
Hypertrophy
Kidney / metabolism,  pathology,  physiology*
Mice
Mitosis
Nephrectomy
Nucleic Acid Precursors / metabolism
RNA, Messenger / metabolism*
RNA, Ribosomal / metabolism*
Chemical
Reg. No./Substance:
0/Nucleic Acid Precursors; 0/RNA, Messenger; 0/RNA, Ribosomal; 9007-49-2/DNA
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Yale J Biol Med
ISSN: 0044-0086
ISSN: 1551-4056
Article Information
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Print publication date: Season: May?Jun Year: 1978
Volume: 51 Issue: 3
First Page: 419 Last Page: 428
ID: 2595727
PubMed Id: 366927
PubMed Id: 366927

Macromolecular Metabolism in Compensatory Renal Hypertrophy
Ronald A. Malt



Article Categories:
  • Article
Series: Biochemical and Molecular Responses to Loss of Renal Mass: Membranes and Protein Synthesis.


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