| Macromolecular and dendrimer-based magnetic resonance contrast agents. | |
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MedLine Citation:
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PMID: 20590365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Magnetic resonance imaging (MRI) is a powerful imaging modality that can provide an assessment of function or molecular expression in tandem with anatomic detail. Over the last 20-25 years, a number of gadolinium-based MR contrast agents have been developed to enhance signal by altering proton relaxation properties. This review explores a range of these agents from small molecule chelates, such as Gd-DTPA and Gd-DOTA, to macromolecular structures composed of albumin, polylysine, polysaccharides (dextran, inulin, starch), poly(ethylene glycol), copolymers of cystamine and cystine with GD-DTPA, and various dendritic structures based on polyamidoamine and polylysine (Gadomers). The synthesis, structure, biodistribution, and targeting of dendrimer-based MR contrast agents are also discussed. |
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Authors:
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Ambika Bumb; Martin W Brechbiel; Peter Choyke |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural; Review |
Journal Detail:
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Title: Acta radiologica (Stockholm, Sweden : 1987) Volume: 51 ISSN: 1600-0455 ISO Abbreviation: Acta Radiol Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-16 Completed Date: 2010-09-14 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 8706123 Medline TA: Acta Radiol Country: England |
Other Details:
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Languages: eng Pagination: 751-67 Citation Subset: IM |
Affiliation:
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Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Albumins
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chemistry Contrast Media / chemistry* Dendrimers / chemistry Gadolinium / chemistry* Humans Macromolecular Substances / chemistry* Magnetic Resonance Imaging* Organometallic Compounds / chemistry* |
| Grant Support | |
ID/Acronym/Agency:
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Z01 SC010051-13/SC/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Albumins; 0/Contrast Media; 0/Dendrimers; 0/Macromolecular Substances; 0/Organometallic Compounds; 7440-54-2/Gadolinium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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