Document Detail

Macromolecular composition of a Cellulomonas sp. cultivated in continuous culture under glucose and zinc limitation.
MedLine Citation:
PMID:  114114     Owner:  NLM     Status:  MEDLINE    
The mutant strain of Cellulomonas sp. (ATCC 21399) was cultivated under glucose and zinc limitation at a variety of growth rates in continuous culture. The growth characteristics and macromolecular composition of the population varied with the limitation imposed and the growth rate. Glucose- and zinc-limited cultures maintained a constant relative protein content. The relative ribonucleic acid content increased, whereas the carbohydrate and deoxyribonucleic acid contents decreased with an increase in the population growth rate in glucose-limited cultures. Free unbound lipid remained constant. The maximum population growth rate in zinc-limited cultures was directly proportional to the zinc concentration and demonstrated a traditional steady-state function. The nucleic acid content increased with increased growth rate; however, the relative nucleic acid content was significantly depressed when compared to glucose limited cells. This manner of cultivation may prove to be a useful tool for the production of single cell protein with lowered nucleic acid content and the elucidation of micronutrient involvement in growth-related processes.
R J Summers; V R Srinivasan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Applied and environmental microbiology     Volume:  37     ISSN:  0099-2240     ISO Abbreviation:  Appl. Environ. Microbiol.     Publication Date:  1979 Jun 
Date Detail:
Created Date:  1979-11-28     Completed Date:  1979-11-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7605801     Medline TA:  Appl Environ Microbiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1079-84     Citation Subset:  IM    
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MeSH Terms
Actinomycetales / genetics,  growth & development,  metabolism*
Bacterial Proteins / biosynthesis*
DNA, Bacterial / biosynthesis*
Dietary Proteins
Glucose / metabolism*
RNA, Bacterial / biosynthesis*
Zinc / metabolism*
Reg. No./Substance:
0/Bacterial Proteins; 0/DNA, Bacterial; 0/Dietary Proteins; 0/RNA, Bacterial; 50-99-7/Glucose; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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