| Macromelia masquerading as an acromegaloid syndrome in an adult with Klippel-Trénaunay syndrome. | |
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MedLine Citation:
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PMID: 18238750 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To describe a case of Klippel-Trénaunay syndrome in an adult patient with symmetric macromelia suggestive of an acromegaloid syndrome. METHODS: We report clinical and laboratory data that were extracted from the medical records of the study patient. We also survey the relevant reports identified through a MEDLINE search of the English-language literature published between January 1, 1996, and June 2, 2007, using the phrase, Klippel-Trénaunay syndrome. RESULTS: A 28-year-old man was admitted to the hospital for weeping lymphedema of the left lower extremity. He had pronounced symmetric hypertrophy of all distal extremities, port-wine stains on his right neck, and varicosities on his left groin. The patient's insulinlike growth factor 1 concentration was 92 ng/mL (reference range, 117-329 ng/mL), which did not support the diagnosis of acromegaly. Klippel-Trénaunay syndrome is a rare congenital condition that belongs to a family of disorders characterized by tissue overgrowth. Classically, the syndrome presents as a triad of vascular malformations, cutaneous hemangiomas, and bone or soft-tissue hypertrophy usually affecting one extremity. The tissue hypertrophy in this syndrome is typically localized and asymmetric. CONCLUSION: The recognition that the tissue hypertrophy in Klippel-Trénaunay syndrome can occur symmetrically will help avoid unnecessary and extensive workup for acromegaly. |
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Authors:
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Erik Lowman; Arshag D Mooradian |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists Volume: 14 ISSN: 1934-2403 ISO Abbreviation: Endocr Pract Publication Date: 2008 Jan-Feb |
Date Detail:
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Created Date: 2008-02-01 Completed Date: 2008-03-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9607439 Medline TA: Endocr Pract Country: United States |
Other Details:
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Languages: eng Pagination: 109-11 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Florida College, Jacksonville, Florida 32209-6511, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acromegaly
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complications,
diagnosis* Adult Diagnosis, Differential Humans Klippel-Trenaunay-Weber Syndrome / diagnosis* Lymphedema / complications, diagnosis* Male Port-Wine Stain / complications, diagnosis* Syndrome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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