| Macrolides in the management of streptococcal pharyngitis/tonsillitis. | |
MedLine Citation:
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PMID: 9109157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The most frequent bacterial cause of pharyngitis/tonsillitis, a common infection in children, is group A beta-hemolytic streptococci. Prevention of acute rheumatic fever is the principal goal of treatment, although antibiotic therapy may also relieve the signs and symptoms of infection, shorten the infective period and prevent suppurative complications. Penicillin is the drug of choice. Alternatives are required, however, for patients allergic to penicillin and may be needed if the rate of bacteriologic failure with penicillin observed during the past decade continues. Erythromycin is generally effective in this infection, but its use, especially in children, is complicated by the need for multiple daily doses, a lengthy treatment period and a high rate of gastrointestinal side effects. The newer macrolides clarithromycin and azithromycin offer lower rates of gastrointestinal complaints and more convenient dosing. Clarithromycin is recommended for twice daily and azithromycin for once daily administration. Because of its prolonged tissue half-life, the recommended duration of azithromycin therapy is 5 days, compared with 10 days for penicillin, erythromycin and clarithromycin. Newer macrolides are rational alternatives to erythromycin for streptococcal pharyngitis/tonsillitis in penicillin-allergic patients. |
Authors:
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M J Tarlow |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Pediatric infectious disease journal Volume: 16 ISSN: 0891-3668 ISO Abbreviation: Pediatr. Infect. Dis. J. Publication Date: 1997 Apr |
Date Detail:
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Created Date: 1997-07-09 Completed Date: 1997-07-09 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8701858 Medline TA: Pediatr Infect Dis J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 444-8 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Birmingham Heartlands Hospital, Bordesley Green East, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Anti-Bacterial Agents / administration & dosage, adverse effects, therapeutic use* Azithromycin / administration & dosage, adverse effects, therapeutic use* Child Child, Preschool Clarithromycin / administration & dosage, adverse effects, therapeutic use* Erythromycin / administration & dosage, adverse effects, therapeutic use* Humans Penicillins / administration & dosage, therapeutic use Pharyngitis / drug therapy* Streptococcal Infections / drug therapy* Tonsillitis / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Penicillins; 114-07-8/Erythromycin; 81103-11-9/Clarithromycin; 83905-01-5/Azithromycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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