| Macrolide antibiotics induce apoptosis of human peripheral lymphocytes in vitro. | |
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MedLine Citation:
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PMID: 15325428 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We previously reported that long-term administration of macrolides (MCL) reduced the number of lymphocytes in bronchoalveolar lavage fluid (BALF) of patients with chronic lower respiratory tract disease. To investigate the anti-inflammatory activity of macrolides, we evaluated their effect on apoptosis of lymphocytes isolated from human peripheral blood. Lymphocytes treated with clarithromycin, azithromycin and josamycin at a final concentration of 200 microg/ml showed positive staining for Annexin V, Fas and Fas ligand using flow cytometry with time at 12-72 h, while other antibiotics did not. Our results suggest that macrolides induce apoptosis of lymphocytes through Fas-Fas ligand pathway and could potentially reduce the number of lymphocytes in the lungs of patients with chronic lower respiratory tract disease. |
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Authors:
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Yuji Ishimatsu; Jun-Ichi Kadota; Tetsuji Iwashita; Towako Nagata; Hiroshi Ishii; Chieko Shikuwa; Hideyuki Kaida; Hiroshi Mukae; Shigeru Kohno |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of antimicrobial agents Volume: 24 ISSN: 0924-8579 ISO Abbreviation: Int. J. Antimicrob. Agents Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-08-24 Completed Date: 2005-02-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9111860 Medline TA: Int J Antimicrob Agents Country: Netherlands |
Other Details:
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Languages: eng Pagination: 247-53 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, School of Medicine, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Annexin A5
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analysis Anti-Bacterial Agents / pharmacology* Antigens, CD95 Apoptosis* Azithromycin / pharmacology Cells, Cultured Clarithromycin / pharmacology Fas Ligand Protein Flow Cytometry Humans Josamycin / adverse effects Lymphocytes / cytology, drug effects* Macrolides / pharmacology* Membrane Glycoproteins / analysis Receptors, Tumor Necrosis Factor / analysis Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Annexin A5; 0/Anti-Bacterial Agents; 0/Antigens, CD95; 0/FAS protein, human; 0/FASLG protein, human; 0/Fas Ligand Protein; 0/Macrolides; 0/Membrane Glycoproteins; 0/Receptors, Tumor Necrosis Factor; 16846-24-5/Josamycin; 81103-11-9/Clarithromycin; 83905-01-5/Azithromycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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