| Macrolide antibiotics broadly and distinctively inhibit cytokine and chemokine production by COPD sputum cells in vitro. | |
| | |
MedLine Citation:
|
PMID: 21315154 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Macrolide antibiotics are known to exert anti-inflammatory actions in vivo, including certain effects in COPD patients. In order to investigate the immunomodulatory profile of activity of macrolide antibiotics, we have studied the effects of azithromycin, clarithromycin, erythromycin and roxithromycin on the in vitro production of a panel of inflammatory mediators from cells isolated from human, steroid-naïve, COPD sputum samples. Macrolide effects were compared to three other commonly used anti-inflammatory compounds, the corticosteroid dexamethasone, the PDE4 inhibitor, roflumilast and the p38 kinase inhibitor, SB203580. Three of the four tested macrolides, azithromycin, clarithromycin and roxithromycin, exhibited pronounced, concentration-related reduction of IL-1β, IL-6, IL-10, TNF-α, CCL3, CCL5, CCL20, CCL22, CXCL1, CXCL5, and G-CSF release. Further slight inhibitory effects on IL-1α, CXCL8, GM-CSF, and PAI-1 production were also observed. Erythromycin was very weakly active. Qualitatively and quantitatively, macrolides exerted distinctive and, compared to other tested classes of compounds, more pronounced immunomodulatory effects, particularly in terms of chemokine (CCL3, CCL5, CCL20, CCL22, and CXCL5), IL-1β, G-CSF and PAI-1 release. The described modulation of inflammatory mediators could potentially contribute to further definition of biomarkers of macrolide anti-inflammatory activity in COPD. |
| | |
Authors:
|
Nikola Marjanović; Martina Bosnar; Francesca Michielin; David R Willé; Tatjana Anić-Milić; Ognjen Culić; Sanja Popović-Grle; Mile Bogdan; Michael J Parnham; Vesna Eraković Haber |
Related Documents
:
|
18324924 - Reverse genetics and the study of the immune response to schistosomes. 9223164 - Is the induction of apoptosis the mechanism of the protective effects of tnf alpha in h... 20966264 - Nematode larvae (order spirurida) in gastric tissues of australian anurans: a compariso... 9854424 - Immune response of electroeluted detergent soluble 29 kda antigen from setaria digitata... 21681844 - Modulation of autophagy influences development and apoptosis in mouse embryos developin... 15531104 - Upregulation of osteopontin in schwann cells of the sciatic nerves of lewis rats with e... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-2-8 |
Journal Detail:
|
Title: Pharmacological research : the official journal of the Italian Pharmacological Society Volume: - ISSN: 1096-1186 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-2-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8907422 Medline TA: Pharmacol Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier Ltd. |
Affiliation:
|
GlaxoSmithKline Research Centre Zagreb Limited, Zagreb, Croatia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The role of endothelin-1 signaling in the fibrosis observed in systemic sclerosis.
Next Document: The boundary structure in the analysis of reversibly interacting systems by sedimentation velocity.