| A Macrocyclic Approach to Tetracycline Natural Products. Investigation of Transannular Alkylations and Michael Additions. | |
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MedLine Citation:
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PMID: 23146096 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A new approach to the tetracycline core structure is presented. The pivotal intermediate is identified as macrocycle III. The two interior bonds (C4a-C12a and C5a-C11a) are to be constructed through sequential transannular Michael additions (III-II) and compression-promoted transannular isoxazole alkylations from intermediate II. |
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Authors:
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Joseph S Wzorek; Thomas F Knöpfel; Ioannis Sapountzis; David A Evans |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-12 |
Journal Detail:
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Title: Organic letters Volume: - ISSN: 1523-7052 ISO Abbreviation: Org. Lett. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100890393 Medline TA: Org Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Chemistry and Chemical Biology, Harvard University , Cambridge, Massachusetts 02138, United States. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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