Document Detail


A Macrocyclic Approach to Tetracycline Natural Products. Investigation of Transannular Alkylations and Michael Additions.
MedLine Citation:
PMID:  23146096     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A new approach to the tetracycline core structure is presented. The pivotal intermediate is identified as macrocycle III. The two interior bonds (C4a-C12a and C5a-C11a) are to be constructed through sequential transannular Michael additions (III-II) and compression-promoted transannular isoxazole alkylations from intermediate II.
Authors:
Joseph S Wzorek; Thomas F Knöpfel; Ioannis Sapountzis; David A Evans
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-12
Journal Detail:
Title:  Organic letters     Volume:  -     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Chemistry and Chemical Biology, Harvard University , Cambridge, Massachusetts 02138, United States.
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