| Macroangiopathy of the upper extremities in progressive systemic sclerosis. | |
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MedLine Citation:
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PMID: 10903189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Raynaud's phenomenon is a hallmark of progressive systemic sclerosis (SSc). While nailfold capillary changes are well known, morphological changes in larger arteries have less been focused on. OBJECTIVE AND METHODS: In the study presented we examined how often in digital subtraction angiography organic changes of the arteries of the fingers, hands and forearms were observed, whether they showed a typical picture like the changes in nailfold capillaries and whether they correlated with cutaneous sclerosis, Raynaud's phenomenon and serological findings. 29 patients were examined, 14 with acroscleroderma and 15 with proximal ascending sclerosis. RESULTS: In 27 of those 29 patients a stenosis of the arteries of the upper extremity was found. The frequency of arterial occlusions decreased from the fingers (26 patients) to the forearms (9 patients with occlusion of the ulnar artery, none with occlusion of the radial artery). The arteries of 47% of patients with proximal ascending sclerosis showed no reactivity towards the alpha-sympatholyticum tolazoline hydrochloride due to severe organic changes while in patients with acroscleroderma only 14% of patients did not respond to tolazoline hydrochloride. The severity of Raynaud's phenomenon did not correlate with the severity of the angiographic findings. In patients with stenoses refractory to tolazoline hydrochloride and in those with occlusions Scl-70 autoantibodies were more frequently positive than in other patients with SSc (44% compared to 23%). CONCLUSION: As in SSc the severity of the organic arterial changes is in close correlation with the extent of the cutaneous sclerosis and with the serological findings the arterial system should gain much more importance in the diagnosis and therapy of SSc. |
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Authors:
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M Stücker; S Quinna; U Memmel; A Röchling; M Traupe; K Hoffmann; O Köster; P Altmeyer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of medical research Volume: 5 ISSN: 0949-2321 ISO Abbreviation: Eur. J. Med. Res. Publication Date: 2000 Jul |
Date Detail:
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Created Date: 2000-08-15 Completed Date: 2000-08-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9517857 Medline TA: Eur J Med Res Country: GERMANY |
Other Details:
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Languages: eng Pagination: 295-302 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Ruhr-University Bochum, Germany. M.Stuecker@derma. de. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angiography, Digital Subtraction Arm / blood supply* Female Humans Male Middle Aged Scleroderma, Systemic / complications*, physiopathology Vascular Diseases / complications* |
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