Document Detail

Macroamylasemia in a patient with multiple myeloma.
MedLine Citation:
PMID:  12400618     Owner:  NLM     Status:  MEDLINE    
We report a rare case of a patient with multiple myeloma who developed hyperamylasemia not associated to hyperamylasuria and without symptoms of pancreatic or salivary disease. This condition suggested the occurrence of macroamylasemia, consisting of macromolecules of amylase bound with immunoglobulins, which are not filtered by the kidneys. Hyperamylasemia was not present at the diagnosis of myeloma and appeared at the relapse of the disease, simultaneously with the appearance of an additional gamma-chain oligoclonal component, suggesting a possible role of these chains in producing macroamylasemia. To our knowledge, this is the first report of macroamylasemia in a patient with multiple myeloma.
Marco Sagristani; Roberto Guariglia; Barbara Pocali; Mafalda De Rienzo; Salvatore Guastafierro; Gaetano Romano; Angelo Tirelli
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  43     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-10-28     Completed Date:  2003-03-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  England    
Other Details:
Languages:  eng     Pagination:  1705-7     Citation Subset:  IM    
Department of Haematology, Transfusion Medicine and Transplant Immunology, Second University of Naples, Italy.
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MeSH Terms
Amylases / blood,  urine
Hyperamylasemia / etiology*
Middle Aged
Multiple Myeloma / complications*,  enzymology
Reg. No./Substance:
EC 3.2.1.-/Amylases

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