Document Detail

Macro and microvasculature in hypertension: therapeutic aspects.
MedLine Citation:
PMID:  18509346     Owner:  NLM     Status:  MEDLINE    
Macrovasculature, microvasculature and the heart determine the structure and function of the circulatory system. Due to the viscoelastic properties of large arteries, the pulsatile pressure and flow that result from intermittent ventricular ejection is smoothed out, so that microvasculature mediates the delivery of nutrients and oxygen to tissues steadily. The disruption of this function, which occurs when microvascular structure develops in response to hypertension, leads to end-organ damage. Microvascular structure is not only the site of vascular resistance, but also the origin of most of the wave reflections generating increased central systolic blood pressure (SBP) in the elderly. Nowadays many data of the literature suggest that hypertension-related damage to the micro and macrovascular system may be manageable through pharmacological agents. Among them, beta-blocking agents and diuretics poorly modify microvascular structure, whereas angiotensin and calcium entry blockade has an opposite effect, thereby reducing central wave reflections and, finally, causing a selective SBP reduction.
M E Safar; D Rizzoni; J Blacher; M L Muiesan; E Agabiti-Rosei
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-05-29
Journal Detail:
Title:  Journal of human hypertension     Volume:  22     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-22     Completed Date:  2008-12-30     Revised Date:  2009-03-12    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  590-5     Citation Subset:  IM    
Faculty of Medicine, Diagnosis and Therapeutic Center, AP-HP, Hôtel-Dieu Hospital, Paris Descartes University, Paris, France.
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MeSH Terms
Blood Vessels / drug effects,  physiopathology
Hypertension / drug therapy*,  physiopathology
Microvessels / drug effects*,  physiopathology
Comment In:
J Hum Hypertens. 2009 Jan;23(1):1-3   [PMID:  18509342 ]

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