Document Detail


Macaca fascicularis, a nonpermissive host for the human filarial parasite Loa loa.
MedLine Citation:
PMID:  2352067     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability of the filarial nematode Loa loa to infect 2 species of primates was studied. The primate species selected were closely related to species known to be susceptible. A mandrill (Mandrillus sphinx) and 6 cynomolgus monkeys (Macaca fascularis) were infected by subcutaneous injection of third-stage larvae of human L. loa from Gabon. The mandrill developed microfilaremia with an estimated prepatent period of 147 days, but microfilariae were not detected in any of the cynomolgus monkeys. Thus, mandrills appear permissive to human L. loa, whereas cynomolgus monkeys are not. Serum antibody responses were examined on western blots of adult L. loa antigens. Preinfection sera from all animals gave no reactions, but, after infection, sera from cynomolgus monkeys reacted more intensely and with more antigens than mandrill sera. Antibodies were still detectable in cynomolgus monkeys 15 mo postinfection. These reactions were compared with those found using human infection sera. Reactions with the cynomolgus monkey sera resembled those found with resistant endemic and amicrofilaremic human sera.
Authors:
M Pinder; A Leclerc; H A Flockhart; T G Egwang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of parasitology     Volume:  76     ISSN:  0022-3395     ISO Abbreviation:  J. Parasitol.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-07-16     Completed Date:  1990-07-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7803124     Medline TA:  J Parasitol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  373-6     Citation Subset:  IM    
Affiliation:
Department of Immunoparasitology, Centre International de Recherches Médicales de Franceville, Gabon.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Helminth / biosynthesis
Blotting, Western
Disease Models, Animal*
Female
Filariasis* / blood,  immunology
Loa / immunology,  isolation & purification
Loiasis* / blood,  immunology
Macaca / parasitology*
Macaca fascicularis / parasitology*
Male
Microfilaria / isolation & purification
Papio
Chemical
Reg. No./Substance:
0/Antibodies, Helminth

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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