Document Detail


Mac-2: a versatile galactose-binding protein of mammalian tissues.
MedLine Citation:
PMID:  8186550     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mac-2 is a member of the S-(soluble) lectin family. Its identification and isolation from a wide variety of cell types and tissues suggest a diversity of roles in various biological systems. The key points to be made are that Mac-2, and the S-lectins in general, by virtue of their recognition of a variety of carbohydrate structures expressed on different glycoproteins, are well placed to exert discrete biological effects according to the distribution of those glycoproteins in tissues and their differential patterns of glycosylation according to developmental status and cell type. In this regard, the lectins are fundamentally different in character to other effector molecules that in general bind to specific receptors to trigger single signal transduction events.
Authors:
R C Hughes
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Glycobiology     Volume:  4     ISSN:  0959-6658     ISO Abbreviation:  Glycobiology     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-06-23     Completed Date:  1994-06-23     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9104124     Medline TA:  Glycobiology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  5-12     Citation Subset:  IM    
Affiliation:
National Institute for Medical Research, Mill Hill, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Antigens, Differentiation / metabolism*
Carbohydrate Metabolism
Carbohydrate Sequence
Cell Differentiation
Embryonic and Fetal Development / genetics
Galactose / metabolism*
Galectin 3
Humans
Lectins / metabolism*
Macrophages / cytology
Molecular Sequence Data
Neoplasm Proteins / metabolism
Chemical
Reg. No./Substance:
0/Antigens, Differentiation; 0/Galectin 3; 0/Lectins; 0/Neoplasm Proteins; 26566-61-0/Galactose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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