| MUC5AC, cytokeratin 20 and HER2 expression and K-RAS mutations within mucinogenic growth in congenital pulmonary airway malformations. | |
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MedLine Citation:
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PMID: 22348416 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To analyse the expression of several mucins (MUC1, MUC2, MUC3, MUC5AC and MUC6), epidermal growth factor receptor (EGFR), v-erb-b2 erythroblastic leukaemia viral oncogene homologue 2 (HER2), thyroid transcription factor-1 (TTF-1), caudal type homeobox 2 (CDX2) and cytokeratin 20 (CK20), and the presence of mutations of EGFR, KRAS and HER2 in congenital pulmonary airway malformations (CPAM). METHODS AND RESULTS: Forty-one cases of CPAM and six pulmonary sequestrations were included. TTF-1 expression was observed in all cases but was not seen in mucinogenic growths in CPAM. CDX2 expression was completely negative. MUC1 expression was noted in 12 (29%) CPAM and in 33% sequestrations. MUC5AC was noted in only five cases (26%) by immunohistochemistry and was found in the mucinogenic proliferations of type 1 CPAM. No immunolabelling was noted for the other mucins. EGFR was expressed variably in almost all cases, while HER2 and CK20 was seen exclusively in the mucinogenic proliferations. All mucinous growths were characterized by KRAS mutations. No EGFR and HER2 gene alterations were identified. CONCLUSIONS: KRAS mutations and MUC5AC, CK20 and HER2 expression was seen in all mucinogenic proliferations, supporting the neoplastic nature of these cytologically bland growths. These findings emphasize the importance of complete surgical resection of such lesions. |
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Authors:
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Giulio Rossi; Bernard Gasser; Giuliana Sartori; Mario Migaldi; Matteo Costantini; Maria Cecilia Mengoli; Silvia Piccioli; Alberto Cavazza; Francesco Rivasi |
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Publication Detail:
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Type: Journal Article Date: 2012-02-20 |
Journal Detail:
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Title: Histopathology Volume: 60 ISSN: 1365-2559 ISO Abbreviation: Histopathology Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-24 Completed Date: 2012-09-26 Revised Date: 2012-10-12 |
Medline Journal Info:
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Nlm Unique ID: 7704136 Medline TA: Histopathology Country: England |
Other Details:
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Languages: eng Pagination: 1133-43 Citation Subset: IM |
Copyright Information:
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© 2012 Blackwell Publishing Ltd. |
Affiliation:
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Section of Pathologic Anatomy, Azienda Ospedaliero-Universitaria Policlinico, Via del Pozzo 71, Modena, Italy. rossi.giulio@policlinico.mo.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma, Mucinous
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genetics,
metabolism,
pathology Adolescent Adult Base Sequence Bronchopulmonary Sequestration / genetics, metabolism, pathology Child Child, Preschool DNA Primers / genetics Female Fetus / abnormalities, metabolism, pathology Genes, ras* Humans Immunohistochemistry Infant Infant, Newborn Keratin-20 / metabolism* Lung / abnormalities*, metabolism*, pathology Lung Neoplasms / genetics, metabolism, pathology Male Middle Aged Mucin 5AC / metabolism* Mutation, Missense Nuclear Proteins / metabolism Receptor, erbB-2 / metabolism* Transcription Factors / metabolism Young Adult |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/Keratin-20; 0/MUC5AC protein, human; 0/Mucin 5AC; 0/Nuclear Proteins; 0/Transcription Factors; 0/thyroid nuclear factor 1; EC 2.7.10.1/ERBB2 protein, human; EC 2.7.10.1/Receptor, erbB-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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