Document Detail

MUC5AC, cytokeratin 20 and HER2 expression and K-RAS mutations within mucinogenic growth in congenital pulmonary airway malformations.
MedLine Citation:
PMID:  22348416     Owner:  NLM     Status:  MEDLINE    
AIMS:   To analyse the expression of several mucins (MUC1, MUC2, MUC3, MUC5AC and MUC6), epidermal growth factor receptor (EGFR), v-erb-b2 erythroblastic leukaemia viral oncogene homologue 2 (HER2), thyroid transcription factor-1 (TTF-1), caudal type homeobox 2 (CDX2) and cytokeratin 20 (CK20), and the presence of mutations of EGFR, KRAS and HER2 in congenital pulmonary airway malformations (CPAM).
METHODS AND RESULTS:   Forty-one cases of CPAM and six pulmonary sequestrations were included. TTF-1 expression was observed in all cases but was not seen in mucinogenic growths in CPAM. CDX2 expression was completely negative. MUC1 expression was noted in 12 (29%) CPAM and in 33% sequestrations. MUC5AC was noted in only five cases (26%) by immunohistochemistry and was found in the mucinogenic proliferations of type 1 CPAM. No immunolabelling was noted for the other mucins. EGFR was expressed variably in almost all cases, while HER2 and CK20 was seen exclusively in the mucinogenic proliferations. All mucinous growths were characterized by KRAS mutations. No EGFR and HER2 gene alterations were identified.
CONCLUSIONS:   KRAS mutations and MUC5AC, CK20 and HER2 expression was seen in all mucinogenic proliferations, supporting the neoplastic nature of these cytologically bland growths. These findings emphasize the importance of complete surgical resection of such lesions.
Giulio Rossi; Bernard Gasser; Giuliana Sartori; Mario Migaldi; Matteo Costantini; Maria Cecilia Mengoli; Silvia Piccioli; Alberto Cavazza; Francesco Rivasi
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Publication Detail:
Type:  Journal Article     Date:  2012-02-20
Journal Detail:
Title:  Histopathology     Volume:  60     ISSN:  1365-2559     ISO Abbreviation:  Histopathology     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-24     Completed Date:  2012-09-26     Revised Date:  2012-10-12    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  England    
Other Details:
Languages:  eng     Pagination:  1133-43     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Section of Pathologic Anatomy, Azienda Ospedaliero-Universitaria Policlinico, Via del Pozzo 71, Modena, Italy.
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MeSH Terms
Adenocarcinoma, Mucinous / genetics,  metabolism,  pathology
Base Sequence
Bronchopulmonary Sequestration / genetics,  metabolism,  pathology
Child, Preschool
DNA Primers / genetics
Fetus / abnormalities,  metabolism,  pathology
Genes, ras*
Infant, Newborn
Keratin-20 / metabolism*
Lung / abnormalities*,  metabolism*,  pathology
Lung Neoplasms / genetics,  metabolism,  pathology
Middle Aged
Mucin 5AC / metabolism*
Mutation, Missense
Nuclear Proteins / metabolism
Receptor, erbB-2 / metabolism*
Transcription Factors / metabolism
Young Adult
Reg. No./Substance:
0/DNA Primers; 0/Keratin-20; 0/MUC5AC protein, human; 0/Mucin 5AC; 0/Nuclear Proteins; 0/Transcription Factors; 0/thyroid nuclear factor 1; EC protein, human; EC, erbB-2

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