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MTRR A66G polymorphism among two caste groups of Uttar Pradesh (India).
MedLine Citation:
PMID:  23806987     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Objective: This study was aimed to evaluate the Methionine synthase reductase (MTRR) A66G mutation in Yadav and Scheduled Caste (SC) population of Uttar Pradesh. Materials and Methods: Blood samples were collected from 100 subjects after taking informed written consent and PCR-RFLP method was used for the analysis of A66G mutation. After NdeI digestion, 66-bp amplicon of normal allele was cut into 22- and 44-bp long fragments, whereas mutant G allele was not digested. Results: Frequencies of genotypes in Yadav population AA, AG, and GG were 12%, 60%, and 28%, respectively, and in SC population, genotypic frequencies were 12% (AA), 52% (AG), and 36% (GG). Conclusion: MTRR gene A66G mutation is found to be polymorphic in both the target populations with G allele frequencies being 0.58 for Yadav and 0.62 for Scheduled Caste.
Authors:
Vandana Rai; Upendra Yadav; Pradeep Kumar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of medical sciences     Volume:  66     ISSN:  1998-3654     ISO Abbreviation:  Indian J Med Sci     Publication Date:    2012 May-Jun
Date Detail:
Created Date:  2013-06-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0373023     Medline TA:  Indian J Med Sci     Country:  India    
Other Details:
Languages:  eng     Pagination:  136-40     Citation Subset:  IM    
Affiliation:
Department of Biotechnology, Human Molecular Genetics Laboratory, VBS Purvanchal University, Jaunpur, Uttar Pradesh, India.
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