Document Detail

MTII-induced reduction of voluntary ethanol drinking is blocked by pretreatment with AgRP-(83-132).
MedLine Citation:
PMID:  14698676     Owner:  NLM     Status:  MEDLINE    
Over the last 30 years, evidence has emerged indicating that the central melanocortin (MC) peptide system is involved with neurobiological responses to drugs of abuse. Recently, rats selectively bred for high ethanol preference were shown to have altered brain levels of MC receptor (MCR) and central infusion of the potent non-selective MCR agonist, melanotan-II (MTII), attenuates their high ethanol drinking. The goal of the present report was to further characterize the effects of MTII on voluntary ethanol consumption. In alcohol preferring C57BL/6 mice with an established history of ethanol drinking, intracerebroventricular (i.c.v.) infusion of a 5.0 microg dose of agouti-related protein (AgRP)-(83-132), a non-selective MCR antagonist, has no effect on 8-h ethanol drinking or food intake. However, pre-treatment with a 5.0 microg dose of (AgRP)-(83-132) significantly blocks MTII-induced (1.0 microg) reduction of 8-h ethanol drinking and food intake, consistent with a competitive antagonist action. I.c.v. infusion of MTII does not cause alteration of blood ethanol levels 2- or 4-h following intraperitoneal (i.p.) injection of a 4.0 g ethanol/kg dose. Finally, when given in an i.p. injection, a 150 microg dose of MTII reduces 8-h ethanol drinking. These data extend recent findings by showing that both central and peripheral administration of MTII reduces ethanol drinking by mice. Additionally, the ability of (AgRP)-(83-132) to block the effects of MTII implies that MTII-induced reduction of ethanol drinking is receptor mediated.
Montserrat Navarro; Inmaculada Cubero; Darin J Knapp; Todd E Thiele
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuropeptides     Volume:  37     ISSN:  0143-4179     ISO Abbreviation:  Neuropeptides     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-30     Completed Date:  2004-04-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8103156     Medline TA:  Neuropeptides     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  338-44     Citation Subset:  IM    
Department of Neurociencia y Ciencias de la Salud, University of Almeria, 04120 Almeria, Spain.
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MeSH Terms
Agouti-Related Protein
Alcohol Drinking / drug therapy*
Alcoholism / drug therapy*
Eating / drug effects
Ethanol / administration & dosage,  blood
Mice, Inbred C57BL
Peptide Fragments / adverse effects,  pharmacology*
Peptides, Cyclic / pharmacology*,  therapeutic use
Receptors, Melanocortin / antagonists & inhibitors*
alpha-MSH / analogs & derivatives*,  pharmacology*,  therapeutic use
Grant Support
Reg. No./Substance:
0/Agouti-Related Protein; 0/Peptide Fragments; 0/Peptides, Cyclic; 0/Receptors, Melanocortin; 0/agouti-related protein-(83-132); 121062-08-6/melanotan-II; 581-05-5/alpha-MSH; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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