| MTHFR C677T polymorphism, folic acid and hyperhomocysteinemia in levodopa treated patients with Parkinson's disease. | |
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MedLine Citation:
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PMID: 15354385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Certain mutations (TT homozygous; CT heterozygous; CC wild-type) of the methylenetetrahydrofolate (MTHFR) gene and long-term levodopa application in patients with Parkinson's disease (PD) support onset of hyperhomocysteinemia. Total plasma homocysteine (t-hcys) depends on B6, B12, folic acid, all of which support remyelination from t-hcys to methionine. Objective of this trial were to compare B6, B12, folic acid and t-hcys levels in plasma of 83 levodopa treated PD patients and 44 controls. PD patients with the CT or TT genotype had significant higher t-hcys levels than controls or PD patients with the CC allele. Concentrations of B6 or B12 did not differ, but folic acid was significant higher in PD patients with the CT mutation. We recommend MTHFR genotyping, t-hcys monitoring and early vitamin supplementation in PD patients. The folic acid increase in PD patients with the CT allele is hypothetically due to an endogenous upregulation of folic acid absorption to decrease t-hcys. |
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Authors:
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D Woitalla; W Kuhn; T Müller |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of neural transmission. Supplementum Volume: - ISSN: 0303-6995 ISO Abbreviation: J. Neural Transm. Suppl. Publication Date: 2004 |
Date Detail:
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Created Date: 2004-09-09 Completed Date: 2004-10-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0425126 Medline TA: J Neural Transm Suppl Country: Austria |
Other Details:
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Languages: eng Pagination: 15-20 Citation Subset: IM |
Affiliation:
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Department of Neurology, St Josef Hospital, Ruhr University, Bochum, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Analysis of Variance Cytosine* Female Folic Acid / blood, genetics* Humans Hyperhomocysteinemia / blood, genetics* Levodopa / pharmacology*, therapeutic use Male Middle Aged Parkinson Disease / blood, drug therapy, genetics* Polymorphism, Genetic* / drug effects Tetrahydrofolates / genetics* Thymine* |
| Chemical | |
Reg. No./Substance:
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0/Levodopa; 0/Tetrahydrofolates; 134-35-0/5-methyltetrahydrofolate; 59-30-3/Folic Acid; 65-71-4/Thymine; 71-30-7/Cytosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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