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The α-MSH analogue AP214 attenuates rise in pulmonary pressure and fall in ejection fraction in lipopolysaccharide-induced systemic inflammatory response syndrome in pigs.
MedLine Citation:
PMID:  21029328     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background:  The effect of an α-melanocyte stimulating hormone (α-MSH) analogue (AP214) on experimentally endotoxin-induced systemic inflammatory response syndrome (SIRS) was studied, because α-MSH in rodent models has shown promise in attenuating inflammatory response markers and associated organ damage in SIRS. SIRS is associated with considerable morbidity and mortality. Consequently, new treatment modalities are still warranted to address the different aspects of the pathophysiological process. Methods:  SIRS was induced by lipopolysaccharide (LPS) (Escherichia coli endotoxin) infusion in anaesthetized Danish Landrace pigs (20-25 kg). The pigs received an α-MSH analogue (AP214) or saline as a bolus at the initiation of the LPS infusion. The hemodynamic response was registered as well as echocardiographic indices of left ventricular function. Results:  The cardiovascular response was recorded together with echocardiographic indices of left ventricular function in control and in intervention animals. AP214 reduced the early peak in pulmonary pressure and pulmonary vascular resistance by approximately 33%. Furthermore, AP214 prevented the decline in left ventricular fractional shortening as observed in the control group. Mean change and standard deviation in fractional shortening (ΔFS) in control group: - 7·3 (4·7), AP214 (low dose): 0·9 (8·2) and AP214 (high dose) 4·1 (6·0), P < 0·05 for both intervention groups versus control. Conclusions:  In the porcine model, the peak increase in pulmonary pressure was attenuated, and the LPS-induced decline in left ventricular function was prevented.
Authors:
Jens Kristensen; Thomas E N Jonassen; Michael Rehling; Else Tønnesen; Erik Sloth; Søren Nielsen; Jørgen Frøkiaer
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Publication Detail:
Type:  Journal Article     Date:  2010-10-04
Journal Detail:
Title:  Clinical physiology and functional imaging     Volume:  31     ISSN:  1475-097X     ISO Abbreviation:  Clin Physiol Funct Imaging     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137604     Medline TA:  Clin Physiol Funct Imaging     Country:  England    
Other Details:
Languages:  eng     Pagination:  54-60     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Clinical Physiology and Functional Imaging © 2010 Scandinavian Society of Clinical Physiology and Nuclear Medicine.
Affiliation:
The Institute of Clinical Medicine, Aarhus University Hospital, Skejby Departments of Clinical Physiology and Nuclear Medicine, Aarhus University Hospital, Skejby Department of Pharmacology, University of Copenhagen, Copenhagen Department of Anaesthesiology, Aarhus University Hospital, Aarhus Water and Salt Research Center, University of Aarhus and Action Pharma, Research Park, Aarhus, Brendstrupgaardsvej, Aarhus N, Denmark.
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