Document Detail


MS and neuromyelitis optica in Martinique (French West Indies).
MedLine Citation:
PMID:  11222796     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVE: A population-based study is reported of MS in French Afro-Caribbeans (FAC) in Martinique. FAC are descendants of interracial mating that occurred between French Caucasians and black Africans in the 17th and the 18th centuries. METHODS: The authors surveyed the entire island of Martinique (area 1,128 km(2), population 357,000) between November 1997 and October 1999. RESULTS: Sixty-two patients (46 females, 16 males, ratio 2.9:1) were identified with definite or probable disease by the Poser criteria. Prevalence for all patients on December 31, 1998, was 17.4/10(5) (95% CI 13.1 to 21.7) and 14.3/10(5) (95% CI 10.4 to 18.2) for clinically definite cases (n = 51). Age range of patients on prevalence day was 17 to 73 years (mean +/- SD 39 +/- 11.3 years). Mean age at onset was 31.2 +/- 11 years. Overall, 9.7% had primary progressive disease and 19.4% had benign MS. A low proportion of definite and probable MS cases had oligoclonal bands in CSF (50.9%). Seventeen patients, 13 of whom were alive on prevalence day, had a relapsing form of neuromyelitis optica. CONCLUSION: The island of Martinique appears to have a low to medium prevalence of MS. MS was almost unknown in FAC in Martinique until the late 1970s. The apparent recent increase may be explained by improved recognition of patients, increased availability of MRI for diagnosis, increased disease awareness among physicians, increased survival of MS patients, or an actual increase in disease frequency.
Authors:
P Cabre; O Heinzlef; H Merle; G G Buisson; O Bera; R Bellance; J C Vernant; D Smadja
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  56     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-06     Completed Date:  2001-04-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  507-14     Citation Subset:  AIM; IM    
Affiliation:
Service de Neurologie, Université Antilles-Guyane, Hôpital Pierre Zobda Quitmann, Fort de France, Martinique (Antilles Françaises). P.cabre@outremer.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Africa / ethnology
Age Factors
Age of Onset
Aged
Alleles
Female
Genes, MHC Class II / genetics*
Haplotypes
Humans
Male
Martinique / epidemiology
Middle Aged
Multiple Sclerosis / epidemiology*,  genetics
Neuromyelitis Optica / epidemiology*,  genetics*
Sex Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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