Document Detail

MRSA in a large German University Hospital: Male gender is a significant risk factor for MRSA acquisition.
MedLine Citation:
PMID:  20941335     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: The continually rising number of hospital acquired infections and particularly MRSA (Methicillin-resistant Staphylococcus aureus) colonization poses a major challenge from both clinical and epidemiological perspectives. The assessment of risk factors is vital in determining the best prevention, diagnosis and treatment strategies.
MATERIALS AND METHODS: We analyzed 798 cases of MRSA in a large German University Hospital over a 7-year period. Data was collected retro- and prospectively including patient age, sex, type of ward and duration of inpatient stay. In addition we analyzed all cases on ICU with regards to cross infection and MRSA genotyping via DNA MicroArray Technology. The years 2004 to 2007 were analyzed with a specific focus on gender.
RESULTS: Male gender is significantly correlated with increased risk of MRSA acquisition (p<0.001), the predominant setting for MRSA is on ICU. 75% of the MRSA positive patients are over 50 years of age (average age 59.8 years). The inpatient time was 4.15 times higher in MRSA carriers compared with non-MRSA cases, however this was not significant. MRSA genotyping on ICU showed mainly the subtypes ST 5, ST 22, ST 228, however cross contamination with identical genotypes was only detected in a minority of cases (5 out of 22).
CONCLUSION: Unlike previous studies which show no or inconclusive evidence of gender as a risk factor, our data confirm that male gender is a significant risk factor for MRSA carrier status. Further research will be required to investigate the aetiology of these findings.
Markus Kupfer; Lutz Jatzwauk; Stephan Monecke; Jana Möbius; Axel Weusten
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Publication Detail:
Type:  Journal Article     Date:  2010-09-21
Journal Detail:
Title:  GMS Krankenhaushygiene interdisziplinär     Volume:  5     ISSN:  1863-5245     ISO Abbreviation:  GMS Krankenhhyg Interdiszip     Publication Date:  2010  
Date Detail:
Created Date:  2010-10-13     Completed Date:  2012-08-27     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  101313359     Medline TA:  GMS Krankenhhyg Interdiszip     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  -    
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