| MRS study of the effects of minocycline on markers of neuronal and microglial integrity in ALS. | |
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MedLine Citation:
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PMID: 20832222 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: Magnetic resonance spectroscopy (MRS) allows to monitor brain metabolites noninvasively in amyotrophic lateral sclerosis (ALS). The objective of this study was to use MRS to monitor the effect of minocycline treatment (200 mg/day) over a short period (6 weeks) on the brain metabolites in the precentral gyrus and brainstem in newly diagnosed ALS patients. METHODS: Ten ALS patients (not on riluzole treatment) were recruited and submitted to single-voxel proton MRS longitudinal examinations (1) before minocycline treatment, (2) 3 weeks and (3) 6 weeks after initiation of treatment. RESULTS: Results did not show the expected decrease of N-acetylaspartate/creatine (NAA/Cr) in the precentral gyrus, and an increased NAA/Cr ratio in the brainstem suggested neuronal recovery. The myo-inositol (mI)/Cr ratio was unchanged in the precentral gyrus, but increased in the brainstem, indicating a glial reaction. CONCLUSIONS: MRS results suggest that minocycline treatment could be beneficial in the early stages of ALS. |
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Authors:
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Abdesslem Khiat; Monique D'Amour; Frédérique Souchon; Yvan Boulanger |
Publication Detail:
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Type: Journal Article Date: 2010-09-15 |
Journal Detail:
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Title: Magnetic resonance imaging Volume: 28 ISSN: 1873-5894 ISO Abbreviation: Magn Reson Imaging Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8214883 Medline TA: Magn Reson Imaging Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1456-60 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Département de Radiologie, Hôpital Saint-Luc du CHUM, Montréal, Canada H2X 3J4. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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