| MRS in Early and Presymptomatic Carriers of a Novel Octapeptide Repeat Insertion in the Prion Protein Gene. | |
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MedLine Citation:
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PMID: 22612156 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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To evaluate the proton magnetic resonance (MR) spectroscopy ((1) H MRS) changes in carriers of a novel octapeptide repeat insertion in the prion protein gene (PRNP) and family history of frontotemporal dementia with ataxia. Four at-risk mutation carriers and 13 controls were compared using single voxel, short TE, (1) H MRS from the posterior cingulate gyrus. The mutation carriers had an increased choline/creatine, P= .003 and increased myoinositol/creatine ratio, P= .003. (1) H MRS identified differences in markers of glial activity and choline metabolism in pre- and early-symptomatic carriers of a novel PRNP gene octapeptide insertion. These findings expand the possible diagnostic utility of (1) H MRS in familial prion disorders. |
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Authors:
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Eric M McDade; Bradley F Boeve; Julie A Fields; Neeraj Kumar; Rosa Rademakers; Matt C Baker; Bsc David S Knopman; Ronald C Petersen; Clifford R Jack; Kejal Kantarci |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-21 |
Journal Detail:
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Title: Journal of neuroimaging : official journal of the American Society of Neuroimaging Volume: - ISSN: 1552-6569 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9102705 Medline TA: J Neuroimaging Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 by the American Society of Neuroimaging. |
Affiliation:
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From the Department of Neurology, University of Pittsburgh, Pittsburgh, PA (EMM); Department of Neurology (BFB, NK, DSK, RCP); Department of Radiology (CRJ, KK); Department of Psychology (JAF) Mayo Clinic, Rochester, MN; and Department of Neurology, Mayo Clinic, Jacksonville, FL (RR, MCB). |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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