| MRS characterization of central neurocytomas using glycine. | |
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MedLine Citation:
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PMID: 21465595 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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This study reports in vivo MRS findings in 11 patients with histologically diagnosed central neurocytomas, which are rare intraventricular tumors of neuronal origin. Single-voxel (1) H MRS was carried out prior to surgery using a point-resolved spectroscopy sequence with TR = 6 s, TE = 135 ms and 128 scans. In vitro high-resolution (1) H spectroscopy was also carried out on two surgically excised samples. The striking features of the spectra from the central neurocytomas were the presence of high glycine, decreased N-acetylaspartate, increased choline and alanine. Retrospective, blind analysis of the spectra by two independent observers correctly identified all but one central neurocytoma based on the presence of glycine. The presence of glycine and prominent choline in the (1) H MR spectrum is a characteristic feature of the central neurocytomas, and could be used to characterize and differentiate them from other brain tumors. Copyright © 2011 John Wiley & Sons, Ltd. |
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Authors:
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Tariq Shah; Rama Jayasundar; Virendera Paul Singh; Chitra Sarkar |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-4 |
Journal Detail:
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Title: NMR in biomedicine Volume: - ISSN: 1099-1492 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8915233 Medline TA: NMR Biomed Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 John Wiley & Sons, Ltd. |
Affiliation:
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Department of NMR, All India Institute of Medical Sciences, New Delhi, India. tariq196@yahoo.com. |
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