Document Detail


MRP14 is elevated in the bronchoalveolar lavage fluid of fibrosing interstitial lung diseases.
MedLine Citation:
PMID:  20550547     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pulmonary fibrosis is defined by an overgrowth of fibroblasts and extracellular matrix deposition, and results in respiratory dysfunction that is often fatal. It is the end stage in many chronic inflammatory interstitial lung diseases (ILD) such as sarcoidosis and idiopathic pulmonary fibrosis (IPF). The myeloid-related proteins (MRPs) belong to the S100 family of calcium-binding proteins and are highly expressed by neutrophils, macrophages and epithelial cells during chronic inflammation. MRP14 stimulates fibroblast proliferation in vitro and is expressed in granulomas from sarcoidosis patients. We hypothesized that MRP14 may be a biomarker for fibrotic interstitial lung diseases. The objective of this study was to investigate whether levels of MRP14 in the bronchoalveolar lavage fluid (BALF) of patients with sarcoidosis and IPF correlate with clinical parameters. We used an enzyme-linked immunosorbent assay (ELISA) to measure MRP14 in BALF of 74 sarcoidosis patients, 54 IPF patients and 19 controls. Mean BALF levels of MRP14 were elevated significantly in IPF (P < 0.001) and sarcoidosis (P < 0.05) patients compared to controls. MRP14 levels were associated linearly with sarcoidosis disease severity based on chest radiographic stage. Moreover, BALF MRP14 levels were correlated inversely with diffusion capacity and forced vital capacity in sarcoidosis patients. In IPF patients, a correlation with BALF neutrophil percentage was found. In conclusion, BALF MRP14 levels are elevated in IPF and sarcoidosis and are associated with disease severity in sarcoidosis. The results support the need for further studies into the role of MRP14 in the pathogenesis of lung fibrosis.
Authors:
N M Korthagen; M M Nagtegaal; C H M van Moorsel; K M Kazemier; J M M van den Bosch; J C Grutters
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Publication Detail:
Type:  Journal Article     Date:  2010-06-09
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  161     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-08-27     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  342-7     Citation Subset:  IM    
Affiliation:
Center for Interstitial Lung Diseases, Department of Pulmonology, St Antonius Hospital Nieuwegein, the Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biological Markers / analysis,  metabolism
Bronchoalveolar Lavage Fluid / chemistry*,  cytology
Calgranulin B / analysis,  metabolism*
Carbon Monoxide / metabolism
Cell Count
Female
Forced Expiratory Volume / physiology
Humans
Idiopathic Pulmonary Fibrosis / metabolism,  pathology,  physiopathology
Lung Diseases, Interstitial / complications,  metabolism*
Male
Middle Aged
Neutrophils / pathology
Pulmonary Diffusing Capacity / physiology
Pulmonary Fibrosis / etiology,  metabolism*
Sarcoidosis, Pulmonary / diagnosis,  metabolism,  physiopathology
Vital Capacity / physiology
Young Adult
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Calgranulin B; 630-08-0/Carbon Monoxide
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