Document Detail


MRP expression in acute myeloid leukemia. An update.
MedLine Citation:
PMID:  10500789     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine the clinical significance of the multidrug resistance protein (MRP) in patients with de novo AML, we have studied MRP expression of leukemic cells at diagnosis and its association with clinical outcome in 127 patients. MRP expression was determined by immunocytochemistry by means of monoclonal antibodies QCRL-1/QCRL-3. MRP expression was low, intermediate and high in 30%, 46% and 24% of the patients, respectively. MRP expression was independent of age and sex of the patients, white blood cell count, FAB subtype, serum lactate dehydrogenase levels and karyotype aberrations. MRP expression had no impact no response to induction chemotherapy. The complete remission rates were 75%, 70% and 64% for patients with low, intermediate and high expression, respectively. Patients with intermediate or high MRP expression showed a trend toward shorter overall survival (p = 0.09) as compared to patients with low MRP expression. MRP does not predict for response to induction chemotherapy but intermediate or high MRP expression might be associated with shorter overall survival of the patients.
Authors:
M Filipits; T Stranzl; G Pohl; R W Suchomel; S Zöchbauer; R Brunner; K Lechner; R Pirker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  457     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1999  
Date Detail:
Created Date:  1999-11-04     Completed Date:  1999-11-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  141-50     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine I, University of Vienna Medical School, Austria.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Disease-Free Survival
Drug Resistance, Multiple*
Female
Humans
Karyotyping
Leukemia, Myeloid, Acute / drug therapy*,  genetics,  mortality,  pathology
Male
Middle Aged
P-Glycoprotein / analysis,  genetics*
Remission Induction
Survival Rate
Chemical
Reg. No./Substance:
0/P-Glycoprotein

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