Document Detail

MRI volumetry of the thalamus in temporal, extratemporal, and idiopathic generalized epilepsy.
MedLine Citation:
PMID:  12707432     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the specificity of thalamic atrophy in epilepsy. METHODS: Thalamic volume measurements were carried out using high-resolution MRI in 40 patients with pharmacologically intractable temporal lobe epilepsy (TLE), 16 patients with extratemporal lobe epilepsy (ETE), and 17 with idiopathic generalized epilepsy (IGE). Thalamic volumes of patients were compared with those of 21 neurologically normal control subjects. Volumes were correlated with duration of epilepsy. The effect of prolonged febrile seizures and generalized seizures on thalamic volumes was examined. RESULTS: Compared with normal control subjects, patients with TLE had a reduction in thalamic volume ipsilateral to the seizure focus. Thalamic volumes in patients with ETE and IGE were not significantly different from those of normal control subjects. In TLE patients, thalamic volumes ipsilateral to the seizure focus were negatively correlated with duration of epilepsy. Patients with a history of prolonged febrile seizures had more severe thalamic atrophy ipsilateral to the seizure focus than those without febrile seizures. CONCLUSIONS: Thalamic atrophy ipsilateral to the seizure focus is found in TLE but not in other forms of focal epilepsy or IGE. In TLE, thalamic atrophy is correlated with duration of disease. Patients with a history of prolonged febrile seizures had smaller thalamic volumes ipsilateral to the seizure focus than those without.
Jun Natsume; Neda Bernasconi; Frederick Andermann; Andrea Bernasconi
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  60     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-22     Completed Date:  2004-01-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1296-300     Citation Subset:  AIM; IM    
Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute and Hospital, Quebec, Canada.
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MeSH Terms
Epilepsy, Generalized / pathology*
Epilepsy, Temporal Lobe / pathology*
Hippocampus / pathology
Image Processing, Computer-Assisted
Magnetic Resonance Imaging*
Middle Aged
Seizures, Febrile / pathology
Thalamus / pathology*
Time Factors
Video Recording

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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