Document Detail

MRI techniques to monitor MS evolution: the present and the future.
MedLine Citation:
PMID:  11971079     Owner:  NLM     Status:  MEDLINE    
Conventional MRI (cMRI) is limited in its ability to provide specific information about pathology in MS. Measures commonly derived from cMRI include T2 lesions, T1-enhanced lesions, atrophy, and possibly T1-hypointense lesions, which have been extensively investigated in many clinical trials. Better MRI measures are needed to advance our understanding of MS and design ideal clinical trials. This article reviews the strengths and weaknesses of the major MRI-based methods used to monitor MS evolution and submits that 1) metrics derived from magnetization transfer MRI, diffusion-weighted MRI, and proton MRS should be implemented to achieve reliable specific in vivo quantification of MS pathology; 2) targeted multiparametric MRI protocols rather than generic application of cMRI should be used in all possible clinical circumstances and trials; and 3) reproducible quantitative MR measures should ideally be used for the assessment of patients but are essential for clinical trials.
Massimo Filippi; Robert I Grossman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neurology     Volume:  58     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-04-23     Completed Date:  2002-05-07     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1147-53     Citation Subset:  AIM; IM    
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy.
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MeSH Terms
Brain / pathology
Image Processing, Computer-Assisted
Magnetic Resonance Imaging / methods*,  trends
Multiple Sclerosis / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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