Document Detail


MRI of the olfactory bulbs and sulci in human fetuses.
MedLine Citation:
PMID:  16341529     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: There is limited knowledge of the MRI pattern of the development of fetal olfactory bulbs and sulci. OBJECTIVE: To describe the MRI appearance of olfactory bulbs and sulci in normal in vivo fetuses according to gestational age. MATERIALS AND METHODS: Olfactory bulbs and sulci were retrospectively assessed on brain MRI examinations of 88 normal fetuses between 24 and 39 weeks gestational age. Two reference centres were involved in the study and both used routine protocols that included axial and coronal T2- and T1-weighted sequences at 1.5 T. The results were compared both with the commonly used neuropathological data in the literature and with personal neuropathological data. Pearson's chi-squared test or Fisher's exact test were performed. One case of olfactory agenesis associated with CHARGE syndrome was identified. RESULTS: T2-weighted coronal sequences were the most sensitive for detecting olfactory bulbs and sulci. Olfactory sulci were significantly better detected from 30 weeks onwards (90.9-100%; P<0.001). MRI showed a posteroanterior development of these sulci. Olfactory bulbs were better detected from 30 to 34 weeks (80-90.9%; P<0.002). Comparison with neuropathological data confirmed the posteroanterior development of the sulci and showed an important delay in detection of the olfactory structures (bulbs and sulci). No difference was observed between the two centres involved. CONCLUSIONS: To date, fetal MRI can depict olfactory sulci from 30 weeks gestational age onwards and olfactory bulbs from 30 to 34 weeks gestational age. This preliminary reference standard is useful to assess the normality of the olfactory system and to diagnose olfactory agenesis.
Authors:
Robin Azoulay; Catherine Fallet-Bianco; Catherine Garel; Sophie Grabar; Gabriel Kalifa; Catherine Adamsbaum
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Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2005-12-08
Journal Detail:
Title:  Pediatric radiology     Volume:  36     ISSN:  0301-0449     ISO Abbreviation:  Pediatr Radiol     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-11     Completed Date:  2006-12-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0365332     Medline TA:  Pediatr Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  97-107     Citation Subset:  IM    
Affiliation:
Department of Radiology, Hôpital Saint Vincent de Paul, Paris V, Faculté de Médecine, 82 Avenue Denfert Rochereau, 75674 Paris Cedex 14, France. svp.radio@svp.ap-hop-paris.fr
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MeSH Terms
Descriptor/Qualifier:
Fetus*
Gestational Age
Humans
Magnetic Resonance Imaging* / standards
Nervous System Malformations / diagnosis*,  pathology
Olfactory Bulb / abnormalities,  anatomy & histology*,  embryology*
Prenatal Diagnosis / instrumentation,  methods
Reference Standards
Retrospective Studies
Syndrome

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