Document Detail

MRI-negative refractory partial epilepsy: role for diffusion tensor imaging in high field MRI.
MedLine Citation:
PMID:  18440782     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our aim is to use the high field MR scanner (3T) to verify whether diffusion tensor imaging (DTI) could help in locating the epileptogenic zone in patients with MRI-negative refractory partial epilepsy. METHOD: Fifteen patients with refractory partial epilepsy who had normal conventional MRI, and 40 healthy volunteers were recruited for the study. DTI was performed on a 3T MR scanner, individual maps of mean diffusivity (MD) and fractional anisotropy (FA) were calculated, and Voxel-Based Analysis (VBA) was performed for individual comparison between patients and controls. RESULT: Voxel-based analysis revealed significant MD increase in variant regions in 13 patients. The electroclinical seizure localization was concurred to seven patients. No patient exhibited regions of significant decreased MD. Regions of significant reduced FA were observed in five patients, with two of these concurring with electroclinical seizure localization. Two patients had regions of significant increase in FA, which were distinct from electroclinical seizure localization. CONCLUSION: Our study's results revealed that DTI is a responsive neuroradiologic technique that provides information about the epileptogenic areas in patients with MRI-negative refractory partial epilepsy. This technique may also helpful in pre-surgical evaluation.
Qin Chen; Su Lui; Chun-Xiao Li; Li-Jun Jiang; Luo Ou-Yang; He-Han Tang; Hui-Fang Shang; Xiao-Qi Huang; Qi-Yong Gong; Dong Zhou
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-28
Journal Detail:
Title:  Epilepsy research     Volume:  80     ISSN:  0920-1211     ISO Abbreviation:  Epilepsy Res.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-16     Completed Date:  2008-10-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703089     Medline TA:  Epilepsy Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  83-9     Citation Subset:  IM    
Department of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
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MeSH Terms
Brain Mapping*
Diffusion Magnetic Resonance Imaging*
Epilepsies, Partial / pathology*
Image Processing, Computer-Assisted
Magnetic Resonance Imaging*
Middle Aged

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