| MRI mismatch-based intravenous thrombolysis for isolated cerebellar infarction. | |
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MedLine Citation:
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PMID: 19246702 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Cerebellar infarctions constitute a significant proportion of ischemic strokes and carry a substantial morbidity and mortality mainly because of swelling in the posterior fossa. No specific acute therapy is established, and patients are usually excluded from intravenous thrombolysis (IVT). METHODS: Two patients presented in an extended time window of 5 and 7 hours to our emergency department with sudden onset of severe cerebellar symptoms. After emergency MRI demonstrated superior cerebellar artery (SCA) occlusion with hypoperfusion of the respective territory and only minor DWI lesions, IVT was administered. Both patients recovered within a few hours after therapy and follow-up MRI on day 1 after treatment demonstrated only minor infarction. CONCLUSIONS: We present to our knowledge the first cases of MRI mismatch-based IVT in an extended time window in patients with isolated SCA-infarctions. More studies are needed to evaluate IVT in this patient population. Modern imaging techniques might be helpful to select patients for therapy in posterior circulation strokes. |
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Authors:
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Martin Köhrmann; Roland Sauer; Hagen B Huttner; Tobias Engelhorn; Arnd Doerfler; Peter D Schellinger |
Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-02-26 |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 40 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-28 Completed Date: 2009-05-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
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Languages: eng Pagination: 1897-9 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Erlangen, Erlangen, Germany. martin.koehrmann@uk-erlangen.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cerebellar Diseases / pathology*, therapy* Cerebellum / blood supply Cerebral Angiography Cerebral Arteries / pathology Cerebral Infarction / pathology*, therapy* Cerebrovascular Circulation / physiology Diffusion Magnetic Resonance Imaging Female Fibrinolytic Agents / administration & dosage, therapeutic use* Humans Injections, Intravenous Magnetic Resonance Angiography Magnetic Resonance Imaging Male Perfusion |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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