Document Detail

MRI mismatch-based intravenous thrombolysis for isolated cerebellar infarction.
MedLine Citation:
PMID:  19246702     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Cerebellar infarctions constitute a significant proportion of ischemic strokes and carry a substantial morbidity and mortality mainly because of swelling in the posterior fossa. No specific acute therapy is established, and patients are usually excluded from intravenous thrombolysis (IVT). METHODS: Two patients presented in an extended time window of 5 and 7 hours to our emergency department with sudden onset of severe cerebellar symptoms. After emergency MRI demonstrated superior cerebellar artery (SCA) occlusion with hypoperfusion of the respective territory and only minor DWI lesions, IVT was administered. Both patients recovered within a few hours after therapy and follow-up MRI on day 1 after treatment demonstrated only minor infarction. CONCLUSIONS: We present to our knowledge the first cases of MRI mismatch-based IVT in an extended time window in patients with isolated SCA-infarctions. More studies are needed to evaluate IVT in this patient population. Modern imaging techniques might be helpful to select patients for therapy in posterior circulation strokes.
Martin Köhrmann; Roland Sauer; Hagen B Huttner; Tobias Engelhorn; Arnd Doerfler; Peter D Schellinger
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-02-26
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  40     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-28     Completed Date:  2009-05-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1897-9     Citation Subset:  IM    
Department of Neurology, University of Erlangen, Erlangen, Germany.
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MeSH Terms
Cerebellar Diseases / pathology*,  therapy*
Cerebellum / blood supply
Cerebral Angiography
Cerebral Arteries / pathology
Cerebral Infarction / pathology*,  therapy*
Cerebrovascular Circulation / physiology
Diffusion Magnetic Resonance Imaging
Fibrinolytic Agents / administration & dosage,  therapeutic use*
Injections, Intravenous
Magnetic Resonance Angiography
Magnetic Resonance Imaging
Reg. No./Substance:
0/Fibrinolytic Agents

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