| MRI-measured bone marrow adipose tissue is inversely related to DXA-measured bone mineral in Caucasian women. | |
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MedLine Citation:
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PMID: 17139464 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Recent studies suggest that bone marrow adipose tissue (BMAT) might play a role in the pathogenesis of osteoporosis. Previous research using regional magnetic resonance spectroscopy methods to measure BMAT has reported inconsistent findings on the relationship between BMAT and dual-energy absorptiometry (DXA)-measured bone mineral density (BMD). METHODS: In the present study, total body and pelvic BMAT were evaluated in 56 healthy women (age 18-88 yrs, mean +/- SD, 47.4 +/- 17.6 yrs; BMI, 24.3 +/- 4.2 kg/m(2)) with T1-weighted whole-body magnetic resonance imaging (MRI). BMD was measured using the whole-body DXA mode (GE Lunar DPX, software version 4.7). RESULTS: A strong negative correlation was observed between pelvic BMAT and BMD (total-body BMD, R = -0.743, P < 0.001; pelvic BMD, R = -0.646, P < 0.001), and between total-body BMAT and BMD (total-body BMD, R = -0.443, P < 0.001; pelvic BMD, R = -0.308, P < 0.001). The inverse association between pelvic BMAT and BMD remained strong after adjusting for age, weight, total body fat, and menopausal status (partial correlation: total-body BMD, R = -0.553, P < 0.001; pelvic BMD, R = -0.513, P < 0.001). BMAT was also highly correlated with age (pelvic BMAT, R = 0.715, P < 0.001; total-body BMAT, R = 0.519, P < 0.001). CONCLUSION: MRI-measured BMAT is thus strongly inversely correlated with DXA-measured BMD independent of other predictor variables. These observations, in the context of DXA technical concerns, support the growing evidence linking BMAT with low bone density. |
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Authors:
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W Shen; J Chen; M Punyanitya; S Shapses; S Heshka; S B Heymsfield |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2006-12-01 |
Journal Detail:
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Title: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA Volume: 18 ISSN: 0937-941X ISO Abbreviation: Osteoporos Int Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-03-30 Completed Date: 2007-05-31 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9100105 Medline TA: Osteoporos Int Country: England |
Other Details:
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Languages: eng Pagination: 641-7 Citation Subset: IM |
Affiliation:
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Obesity Research Center, St. Luke's-Roosevelt Hospital and Institute of Human Nutrition, Columbia University, 1090 Amsterdam Avenue, 14H, New York, NY 10025, USA. WS2003@Columbia.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Adipose Tissue / anatomy & histology* Adolescent Adult Age Factors Aged Aged, 80 and over Body Weight / physiology Bone Density / physiology* Bone Marrow / anatomy & histology* European Continental Ancestry Group Female Humans Magnetic Resonance Imaging* Middle Aged Osteoporosis / etiology |
| Grant Support | |
ID/Acronym/Agency:
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P01 DK042618-15/DK/NIDDK NIH HHS; R01 DK42618/DK/NIDDK NIH HHS; R21 DK066360-02/DK/NIDDK NIH HHS; R21 DK66360-01/DK/NIDDK NIH HHS |
| Comments/Corrections | |
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