| The MRI-measured arterial input function resulting from a bolus injection of Gd-DTPA in a rat model of stroke slightly underestimates that of Gd-[14C]DTPA and marginally overestimates the blood-to-brain influx rate constant determined by Patlak plots. | |
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MedLine Citation:
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PMID: 20512853 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hypothesis that the arterial input function (AIF) of gadolinium-diethylenetriaminepentaacetic acid injected by intravenous bolus and measured by the change in the T(1)-relaxation rate (Delta R(1); R(1) = 1/T(1)) of superior sagittal sinus blood (AIF-I) approximates the AIF of (14)C-labeled gadolinium-diethylenetriaminepentaacetic acid measured in arterial blood (reference AIF) was tested in a rat stroke model (n = 13). Contrary to the hypothesis, the initial part of the Delta R(1)-time curve was underestimated, and the area under the normalized curve for AIF-I was about 15% lower than that for the reference AIF. Hypothetical AIFs for gadolinium-diethylenetriaminepentaacetic acid were derived from the reference AIF values and averaged to obtain a cohort-averaged AIF. Influx rate constants (K(i)) and proton distribution volumes at zero time (V(p) + V(o)) were estimated with Patlak plots of AIF-I, hypothetical AIFs, and cohort-averaged AIFs and tissue Delta R(1) data. For the regions of interest, the K(i)s estimated with AIF-I were slightly but not significantly higher than those obtained with hypothetical AIFs and cohort-averaged AIF. In contrast, V(p) + V(o) was significantly higher when calculated with AIF-I. Similar estimates of K(i) and V(p) + V(o) were obtained with hypothetical AIFs and cohort-averaged AIF. In summary, AIF-I underestimated the reference AIF; this shortcoming had little effect on the K(i) calculated by Patlak plot but produced a significant overestimation of V(p) + V(o). |
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Authors:
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Tavarekere N Nagaraja; Kishor Karki; James R Ewing; George W Divine; Joseph D Fenstermacher; Clifford S Patlak; Robert A Knight |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 63 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-09-23 Revised Date: 2012-12-20 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 1502-9 Citation Subset: IM |
Copyright Information:
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(c) 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Anesthesiology, Henry Ford Hospital, Detroit, Michigan 48202, USA. annta@neuro.hfh.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood-Brain Barrier / physiopathology* Disease Models, Animal Gadolinium DTPA / blood* Humans Injections, Intra-Arterial Magnetic Resonance Imaging Rats Stroke* / radiography |
| Grant Support | |
ID/Acronym/Agency:
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1R01CA135329/CA/NCI NIH HHS; 1R01HL70023/HL/NHLBI NIH HHS; 1R01NS058630/NS/NINDS NIH HHS; 1R01NS38540/NS/NINDS NIH HHS; R01 CA135329/CA/NCI NIH HHS; R01 CA135329-03/CA/NCI NIH HHS; R01 HL070023-04/HL/NHLBI NIH HHS; R01 NS038540-04/NS/NINDS NIH HHS; R01 NS058630-02/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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80529-93-7/Gadolinium DTPA |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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