Document Detail


The MRI-measured arterial input function resulting from a bolus injection of Gd-DTPA in a rat model of stroke slightly underestimates that of Gd-[14C]DTPA and marginally overestimates the blood-to-brain influx rate constant determined by Patlak plots.
MedLine Citation:
PMID:  20512853     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hypothesis that the arterial input function (AIF) of gadolinium-diethylenetriaminepentaacetic acid injected by intravenous bolus and measured by the change in the T(1)-relaxation rate (Delta R(1); R(1) = 1/T(1)) of superior sagittal sinus blood (AIF-I) approximates the AIF of (14)C-labeled gadolinium-diethylenetriaminepentaacetic acid measured in arterial blood (reference AIF) was tested in a rat stroke model (n = 13). Contrary to the hypothesis, the initial part of the Delta R(1)-time curve was underestimated, and the area under the normalized curve for AIF-I was about 15% lower than that for the reference AIF. Hypothetical AIFs for gadolinium-diethylenetriaminepentaacetic acid were derived from the reference AIF values and averaged to obtain a cohort-averaged AIF. Influx rate constants (K(i)) and proton distribution volumes at zero time (V(p) + V(o)) were estimated with Patlak plots of AIF-I, hypothetical AIFs, and cohort-averaged AIFs and tissue Delta R(1) data. For the regions of interest, the K(i)s estimated with AIF-I were slightly but not significantly higher than those obtained with hypothetical AIFs and cohort-averaged AIF. In contrast, V(p) + V(o) was significantly higher when calculated with AIF-I. Similar estimates of K(i) and V(p) + V(o) were obtained with hypothetical AIFs and cohort-averaged AIF. In summary, AIF-I underestimated the reference AIF; this shortcoming had little effect on the K(i) calculated by Patlak plot but produced a significant overestimation of V(p) + V(o).
Authors:
Tavarekere N Nagaraja; Kishor Karki; James R Ewing; George W Divine; Joseph D Fenstermacher; Clifford S Patlak; Robert A Knight
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  63     ISSN:  1522-2594     ISO Abbreviation:  Magn Reson Med     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-09-23     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1502-9     Citation Subset:  IM    
Copyright Information:
(c) 2010 Wiley-Liss, Inc.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood-Brain Barrier / physiopathology*
Disease Models, Animal
Gadolinium DTPA / blood*
Humans
Injections, Intra-Arterial
Magnetic Resonance Imaging
Rats
Stroke* / radiography
Grant Support
ID/Acronym/Agency:
1R01CA135329/CA/NCI NIH HHS; 1R01HL70023/HL/NHLBI NIH HHS; 1R01NS058630/NS/NINDS NIH HHS; 1R01NS38540/NS/NINDS NIH HHS; R01 CA135329/CA/NCI NIH HHS; R01 CA135329-03/CA/NCI NIH HHS; R01 HL070023/HL/NHLBI NIH HHS; R01 HL070023-04/HL/NHLBI NIH HHS; R01 NS038540-04/NS/NINDS NIH HHS; R01 NS058630-02/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
K2I13DR72L/Gadolinium DTPA
Comments/Corrections

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