Document Detail

MRI in sporadic Creutzfeldt-Jakob disease: correlation with clinical and neuropathological data.
MedLine Citation:
PMID:  9541914     Owner:  NLM     Status:  MEDLINE    
To ascertain whether increased grey matter signal intensity on T2-weighted images in patients with sporadic Creutzfeldt-Jakob disease (CJD) corresponds to the stage and severity of this disease, we correlated MRI findings in four of our own and previously reported patients with sporadic CJD with the clinical variants, neuropathological changes at autopsy, duration of the disease and survival time after MRI examination. Of 15 patients with the extrapyramidal type of CJD, 10 showed increased signal in the basal ganglia on T2-weighted images. One of seven patients with the Heidenhain variant had increased signal in the occipital cortex. Patients without increased grey matter signal intensity had a longer overall duration of CJD (P = 0.035). Although the interval between onset of neurological symptoms and MRI was not different, patients without increased grey matter signal also survived longer after MRI examination (P = 0.022).
H Urbach; J Klisch; H K Wolf; D Brechtelsbauer; S Gass; L Solymosi
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Neuroradiology     Volume:  40     ISSN:  0028-3940     ISO Abbreviation:  Neuroradiology     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-05-19     Completed Date:  1998-05-19     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  1302751     Medline TA:  Neuroradiology     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  65-70     Citation Subset:  IM    
Department of Neuroradiology, University of Würzburg, Germany.
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MeSH Terms
Brain / pathology*
Creutzfeldt-Jakob Syndrome / mortality,  pathology*
Magnetic Resonance Imaging
Middle Aged
Time Factors

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