| MRI in the presurgical evaluation of patients with frontal lobe epilepsy and children with temporal lobe epilepsy: pathologic correlation and prognostic importance. | |
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MedLine Citation:
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PMID: 1563338 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We performed magnetic resonance imaging (MRI) using a high-field strength magnet (1.5 T) in two series of 53 patients with intractable partial epilepsy of frontal lobe or temporal lobe origin who subsequently received ablative surgery for their seizure disorder. In the first series of patients the pathologic correlation and prognostic importance of an MRI-identified lesion in the frontal lobe were assessed. Twenty-five percent of the patients with negative MRI studies and 67% of patients with neuroimaging abnormalities restricted to the frontal lobe, were seizure-free at a minimum duration of follow-up of 1 year. None of the patients with a multilobar MRI-detected abnormality was seizure-free postoperatively. In the second study the sensitivity and specificity of MRI-based hippocampal volumetry was determined in pediatric patients with partial epilepsy of temporal lobe origin unrelated to foreign-tissue pathology. Hippocampal formation atrophy in the epileptic temporal lobe was identified in 63% of patients. The sensitivity and specificity of hippocampal volumetry was 100% in patients with mesial temporal sclerosis. The presence of an MRI-detected epileptogenic lesion in the frontal lobe and hippocampal formation atrophy in the temporal lobe may correlate with the underlying pathology and affect the identification of potential candidates for epilepsy surgery. |
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Authors:
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G D Cascino; C R Jack; J E Parisi; W R Marsh; P J Kelly; F W Sharbrough; K A Hirschorn; M R Trenerry |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Epilepsy research Volume: 11 ISSN: 0920-1211 ISO Abbreviation: Epilepsy Res. Publication Date: 1992 Mar |
Date Detail:
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Created Date: 1992-05-15 Completed Date: 1992-05-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8703089 Medline TA: Epilepsy Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 51-9 Citation Subset: IM |
Affiliation:
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Epilepsy Service, Mayo Clinic, Rochester, MN. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Analysis of Variance Child Child, Preschool Electroencephalography Epilepsy, Frontal Lobe / pathology*, physiopathology, surgery Epilepsy, Temporal Lobe / pathology*, physiopathology, surgery Female Humans Magnetic Resonance Imaging Male Middle Aged Preoperative Care Prognosis Retrospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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