Document Detail


MRI in experimental stroke.
MedLine Citation:
PMID:  21279618     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stroke is the third leading cause of death and the leading cause of long-term disability in the United States. Brain imaging data from experimental stroke models and stroke patients have shown that there is often a gradual progression of potentially reversible ischemic injury toward infarction. A central core with severely compromised cerebral blood flow (CBF) is surrounded by a rim of moderately ischemic tissue with diminished CBF and impaired electrical activity but preserved cellular metabolism, often referred to as the "ischemic penumbra." Re-establishing tissue perfusion and/or treating with neuroprotective drugs in a timely fashion is expected to salvage some ischemic tissues. Diffusion-weighted imaging (DWI) based on magnetic resonance imaging (MRI) in which contrast is based on water apparent diffusion coefficient (ADC) can detect ischemic injury within minutes after onsets, whereas computed tomography and other imaging modalities fail to detect stroke injury for at least a few hours. Along with quantitative perfusion imaging, the perfusion-diffusion mismatch which approximates the ischemic penumbra could be defined non-invasively. This chapter describes stroke modeling, perfusion, diffusion, and some other MRI techniques commonly used to image acute stroke and, finally, image analysis pertaining to experimental stroke imaging.
Authors:
Timothy Q Duong
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  711     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2011  
Date Detail:
Created Date:  2011-01-31     Completed Date:  2011-05-05     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  473-85     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Image Processing, Computer-Assisted
Magnetic Resonance Imaging / methods*
Male
Rats
Stroke / diagnosis*,  surgery
Grant Support
ID/Acronym/Agency:
R01 NS045879/NS/NINDS NIH HHS; R01 NS045879/NS/NINDS NIH HHS; R01 NS045879-02/NS/NINDS NIH HHS; R01 NS045879-03/NS/NINDS NIH HHS; R01 NS045879-04/NS/NINDS NIH HHS; R01 NS045879-05/NS/NINDS NIH HHS; R01 NS045879-06/NS/NINDS NIH HHS; R01 NS045879-07/NS/NINDS NIH HHS; R01 NS045879-08/NS/NINDS NIH HHS; R01 NS045879-09/NS/NINDS NIH HHS
Comments/Corrections

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