Document Detail

MRI follow-up in a case of clinically diagnosed Creutzfeld-Jakob disease.
MedLine Citation:
PMID:  9510575     Owner:  NLM     Status:  MEDLINE    
We report the case of a 75-year-old woman suffering from Creutzfeld-Jakob disease (CJD). As brain biopsy was refused, diagnosis had to be based on clinical examination, EEC and findings on cranial MRI. Over a 4-month period MRI examinations demonstrated progressive cortical atrophy and bilateral enhanced signal intensity on T2-weighted images of caudate nuclei and putamina indicating development of spongioform degeneration. As clinical course and the characteristic pattern of brain lesions corresponded to cases of neuropathologically confirmed CJD, we suggest that MRI should be considered a valuable diagnostic tool in clinical diagnosis of the disease.
A Hutzelmann; J Biederer
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European radiology     Volume:  8     ISSN:  0938-7994     ISO Abbreviation:  Eur Radiol     Publication Date:  1998  
Date Detail:
Created Date:  1998-04-30     Completed Date:  1998-04-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9114774     Medline TA:  Eur Radiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  421-3     Citation Subset:  IM    
Department of Radiology, Christian-Albrechts-Universität zu Kiel, Arnold Heller Strasse 9, D-24105 Kiel, Germany.
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MeSH Terms
Autonomic Nervous System Diseases / physiopathology
Brain / pathology*
Caudate Nucleus / pathology
Cerebral Cortex / pathology
Creutzfeldt-Jakob Syndrome / diagnosis*,  physiopathology
Dementia / physiopathology
Disease Progression
Fatal Outcome
Follow-Up Studies
Magnetic Resonance Imaging*
Putamen / pathology
Spasm / physiopathology

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