Document Detail

MRI findings in patients with affective disorder: a meta-analysis.
MedLine Citation:
PMID:  9296545     Owner:  NLM     Status:  MEDLINE    
A review of the literature on primarily magnetic resonance imaging (MRI) scans of patients with affective disorders is presented. Several studies have indicated an increased ventricle/brain ratio and other signs of cerebral atrophy, as well as an increased frequency of lesions (so-called signal hyperintensities) in the brains of unipolar and bipolar patients. This notion is strongly supported by two meta-analyses performed in the present study. The lesions are often localized in the frontal lobes and the basal ganglia, indicating a defective basal ganglia/frontal circuit, and are correlated with the degree of cognitive impairment seen in these conditions. No studies have indicated that psychoactive drugs or electroconvulsive therapy (ECT) might cause the lesions, but on the other hand they can probably increase the risk of delirium complicating the treatment.
P Videbech
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Publication Detail:
Type:  Journal Article; Meta-Analysis    
Journal Detail:
Title:  Acta psychiatrica Scandinavica     Volume:  96     ISSN:  0001-690X     ISO Abbreviation:  Acta Psychiatr Scand     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-23     Completed Date:  1997-10-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370364     Medline TA:  Acta Psychiatr Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  157-68     Citation Subset:  IM    
Department of Biological Psychiatry, Psychiatric Hospital in Arhus, Risskov, Denmark.
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MeSH Terms
Basal Ganglia / pathology
Bipolar Disorder / diagnosis
Brain / pathology*
Brain Damage, Chronic / diagnosis
Cerebral Ventricles / pathology
Delirium, Dementia, Amnestic, Cognitive Disorders / diagnosis*
Frontal Lobe / pathology
Magnetic Resonance Imaging*
Middle Aged
Mood Disorders / diagnosis*

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