| MRI findings in haemophilic joints treated with radiosynoviorthesis with development of an MRI scale of joint damage. | |
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MedLine Citation:
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PMID: 10792474 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We hypothesized that magnetic resonance imaging (MRI) scans taken prior to radiosynoviorthesis may be predictive of response to the procedure in persons with haemophilia. Specifically, response would be inversely related to the severity of synovial hyperplasia. Radiosynoviorthesis was administered to 21 joints with recurrent haemorrhage (target joints). A detailed self-report of haemorrhage history, joint evaluation with scoring according to the World Federation of Haemophilia orthopaedic joint and pain scales, plain radiographs, and MRI studies of the joints were performed pre- and post-radiosynoviorthesis. To augment comparison of the MRI findings to those assessed using the Arnold-Hilgartner and Pettersson scales, a provisional MRI scale for evaluation of haemophilic arthropathy was designed. We found the MRI findings prior to the procedure were not predictive of clinical response; independent of the severity of synovial hyperplasia, most joints bled less and showed improvement by the WFH orthopaedic score. There was generally no change in the severity of synovial hyperplasia after the procedure. We conclude that MRI evaluation is not routinely indicated prior to radiosynoviorthesis. |
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Authors:
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R Nuss; R F Kilcoyne; S Geraghty; A L Shroyer; J W Rosky; S Mawhinney; J Wiedel; M Manco-Johnson |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Haemophilia : the official journal of the World Federation of Hemophilia Volume: 6 ISSN: 1351-8216 ISO Abbreviation: Haemophilia Publication Date: 2000 May |
Date Detail:
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Created Date: 2000-07-14 Completed Date: 2000-07-14 Revised Date: 2009-10-21 |
Medline Journal Info:
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Nlm Unique ID: 9442916 Medline TA: Haemophilia Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 162-9 Citation Subset: IM |
Affiliation:
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Mountain States Regional Haemophilia and Thrombosis Center, Denver, Colorado, USA. rachelle.nuss@uchsc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Ankle / pathology, radiation effects Child Elbow / pathology, radiation effects Follow-Up Studies Hemarthrosis / diagnosis*, etiology, radiotherapy* Hemophilia A / blood, complications*, pathology, radiotherapy Hemophilia B / blood, complications, pathology Humans Hyperplasia / diagnosis, radiography, radiotherapy Knee / pathology, radiation effects Magnetic Resonance Imaging* Phosphorus Radioisotopes / therapeutic use Severity of Illness Index Synovial Membrane / pathology, radiation effects |
| Grant Support | |
ID/Acronym/Agency:
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5MO1RR00069/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Phosphorus Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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