| MRI evaluation of residual tumor size after neoadjuvant endocrine therapy vs. neoadjuvant chemotherapy. | |
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MedLine Citation:
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PMID: 21664779 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIM: To investigate if there is any difference in evaluation of residual tumor size after neoadjuvant chemotherapy (NAC) and neoadjuvant endocrine therapy (NAE). METHODS: Seventy-eight tumors in 57 patients were prospectively enrolled. Residual tumor sizes in contrast-enhanced MRI after NAC and NAE were compared with those measured on surgical specimen by using linear regression analyses. The line slope values >1 indicates overestimation by MRI. Differences in types of shrinkage patterns: concentric shrinkage (CS) and dendritic shrinkage (DS) were also investigated. RESULTS: Fifty lesions were treated with NAC and 28 lesions were treated with NAE. Shrinkage patterns were CS in 33 lesions and in 45 lesions. The slopes values were 0.75 (R=0.92) and 0.70 (R=0.90) for NAC and NAE, respectively, and no significant difference was observed (p=0.46). However, they were 1.02 (R=0.92) and 0.68 (R=0.92), respectively for CS and DS with significant difference (p<0.01). The difference between CS and DS was found only in a subgroup with size by MRI >20mm. CONCLUSION: Contrast enhanced MRI enabled fairly accurate measurement in NAE as well as in NAC. |
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Authors:
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Kazuna Takeda; Shotaro Kanao; Tomohisa Okada; Takayuki Ueno; Masakazu Toi; Hiroshi Ishiguro; Yoshiki Mikami; Shiro Tanaka; Kaori Togashi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-9 |
Journal Detail:
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Title: European journal of radiology Volume: - ISSN: 1872-7727 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106411 Medline TA: Eur J Radiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin Kawaharacho, Sakyoku, Kyoto 606-8507, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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