| MRI estimation of global brain oxygen consumption rate. | |
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MedLine Citation:
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PMID: 20407465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Measuring the global cerebral metabolic rate of oxygen (CMRO(2)) is a valuable tool for assessing brain vitality and function. Measurement of blood oxygen saturation (HbO(2)) and flow in the major cerebral outflow and inflow vessels can provide a global estimate of CMRO(2). We demonstrate a rapid noninvasive method for quantifying CMRO(2) by simultaneously measuring venous oxygen saturation in the superior sagittal sinus with magnetic resonance susceptometry-based oximetry, a technique that exploits the intrinsic susceptibility of deoxygenated hemoglobin, and the average blood inflow rate with phase-contrast magnetic resonance imaging. The average venous HbO(2), cerebral blood flow, and global CMRO(2) values in eight healthy, normal study subjects were 64%+/-4%, 45.2+/-3.2 mL per 100 g per minute, and 127+/-7 micromol per 100 g per minute, respectively. These values are in good agreement with those reported in literature. The technique described is noninvasive, robust, and reproducible for in vivo applications, making it ideal for use in clinical settings for assessing the pathologies associated with dysregulation of cerebral metabolism. In addition, the short acquisition time (approximately 30 seconds) makes the technique suitable for studying the temporal variations in CMRO(2) in response to physiologic challenges. |
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Authors:
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Varsha Jain; Michael C Langham; Felix W Wehrli |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-04-21 |
Journal Detail:
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Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 30 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-02 Completed Date: 2010-10-19 Revised Date: 2011-12-16 |
Medline Journal Info:
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Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
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Languages: eng Pagination: 1598-607 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Algorithms Brain Chemistry / physiology* Carotid Artery, Internal / physiology Cerebrovascular Circulation / physiology Data Interpretation, Statistical Humans Image Processing, Computer-Assisted Kinetics Magnetic Resonance Imaging / methods* Male Oximetry Oxygen Consumption / physiology* Phantoms, Imaging Vertebral Artery / physiology |
| Grant Support | |
ID/Acronym/Agency:
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R01 MH080892-01A2/MH/NIMH NIH HHS; R01 MH080892-01A2S1/MH/NIMH NIH HHS; R01 MH080892-03/MH/NIMH NIH HHS; R01 MH080892-04/MH/NIMH NIH HHS; R01-MH080892/MH/NIMH NIH HHS; R21-HL088182/HL/NHLBI NIH HHS |
| Comments/Corrections | |
Erratum In:
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J Cereb Blood Flow Metab. 2011 May;31(5):1336 J Cereb Blood Flow Metab. 2010 Dec;30(12):1987 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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