| MRI estimation of the arterial input function in mice. | |
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MedLine Citation:
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PMID: 13678084 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RATIONAL AND OBJECTIVES: Dynamic contrast-enhanced (DCE) MRI offers the potential to provide quantitative maps of tumor perfusion parameters and is therefore expected to play an important role in the study of cancer in small animal models. Extraction of such information from DCE-MRI data requires a methodology for determination of the arterial input function (AIF) for the target tissues. An MRI based method for observation of the AIF in a mouse model is demonstrated in the present report. MATERIALS AND METHODS: A series of short-axis cardiac images was acquired during the first pass of a bolus of Gadodiamide using a low-resolution, EEG-gated, saturation-recovery gradient echo imaging sequence. The AIF was then extracted from the observed signal intensity changes in the left ventricle (LV) blood pool. RESULTS: The proposed technique provides sufficient temporal and spatial resolution to accurately characterize the AIF of Gadodiamide in mouse models. The AIF was observed in 4 mice and was found to be qualitatively similar to that previously observed in larger animals. However, significant inter-animal variability in the precise form of the AIF was evident. CONCLUSIONS: The proposed method for determination of AIF in mice has been shown to be effective and reliable. The inter-animal variability observed in the present study suggests that the AIF should be measured in each animal undergoing analysis by DCE-MRI. |
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Authors:
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Stephen Pickup; Rong Zhou; Jerry Glickson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Academic radiology Volume: 10 ISSN: 1076-6332 ISO Abbreviation: Acad Radiol Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-09-18 Completed Date: 2004-01-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9440159 Medline TA: Acad Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 963-8 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of Pennsylvania, B1 Stellar Chance Laboratories, 422 Curie Blvd., Philadelphia, PA 19104, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Contrast Media* Coronary Circulation* Female Gadolinium DTPA / diagnostic use* Injections, Intravenous Magnetic Resonance Imaging / methods* Mice Mice, Inbred C3H Neoplasms, Experimental / blood supply |
| Grant Support | |
ID/Acronym/Agency:
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R24 CA83105/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 122795-43-1/gadodiamide; 80529-93-7/Gadolinium DTPA |
| Comments/Corrections | |
Comment In:
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Acad Radiol. 2003 Sep;10(9):961-2
[PMID:
13678083
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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