| MRI detection of tissue pathology beyond atrophy in Alzheimer's disease: introducing T2-VBM. | |
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MedLine Citation:
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PMID: 21473918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Voxel-based morphometry (VBM) of T1-weighted magnetic resonance (MR) images has been widely used to identify regional atrophy in neurodegenerative conditions such as Alzheimer's disease (AD). In theory, however, T2-weighting should be more sensitive to tissue pathology, though until recently, volumetric T2-weighted images were unavailable. We tested the hypothesis that T2-VBM would be more sensitive to grey matter pathology in AD than T1-VBM using the recently-developed SPACE acquisition, which provides true-3D, high-resolution T2-weighted images. This was contrasted to conventional T1-weighted MPRAGE images acquired at the same session and resolution. All of the atrophic regions identified with T1-VBM were also identified with T2-VBM. Additional abnormalities were, however, identified with T2-VBM and the distribution of these bore a striking resemblance to the distribution of amyloid plaque deposition in AD, suggesting that T2-VBM detects signal changes due to histopathology over and above those attributable to atrophy. In keeping with this hypothesis, the relevant statistical tests demonstrated that the difference in sensitivity was caused by an apparent change in T2-weighted signal intensity that was not present in T1-weighted images. These results suggest that T2-VBM has the potential to advance VBM beyond atrophy detection to more expansive applications in tissue pathology mapping. |
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Authors:
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Lara Z Diaz-de-Grenu; Julio Acosta-Cabronero; Joao M S Pereira; George Pengas; Guy B Williams; Peter J Nestor |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-04-05 |
Journal Detail:
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Title: NeuroImage Volume: 56 ISSN: 1095-9572 ISO Abbreviation: Neuroimage Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-31 Completed Date: 2011-10-17 Revised Date: 2012-01-11 |
Medline Journal Info:
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Nlm Unique ID: 9215515 Medline TA: Neuroimage Country: United States |
Other Details:
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Languages: eng Pagination: 1946-53 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Herchel Smith Building for Brain and Mind Sciences, Department of Clinical Neurosciences, University of Cambridge School of Clinical Medicine, Cambridge, UK. ld369@cam.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Alzheimer Disease / pathology* Atrophy / pathology Brain / pathology* Brain Mapping / methods Female Humans Image Interpretation, Computer-Assisted / methods* Imaging, Three-Dimensional / methods* Magnetic Resonance Imaging / methods* Male Sensitivity and Specificity |
| Grant Support | |
ID/Acronym/Agency:
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//Medical Research Council |
| Comments/Corrections | |
Comment In:
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Neuroimage. 2012 Jan 16;59(2):885-6
[PMID:
21763436
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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