Document Detail


MRI-defined subcortical ischemic vascular disease: baseline clinical and neuropsychological findings. The LADIS Study.
MedLine Citation:
PMID:  19218799     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Subcortical ischemic vascular disease (SIVD) is a common, but often overlooked cause of vascular cognitive impairment. Diagnostic research criteria for SIVD are based on magnetic resonance imaging (MRI) findings including substantial white matter lesions (WML) and multiple lacunar infarcts. Empirical studies validating these imaging criteria are still few. The purpose of the study was to describe the clinical and cognitive characteristics of the MRI-defined SIVD in a mixed sample of functionally independent elderly subjects with WML. METHODS: The subjects of the Leukoaraiosis and Disability (LADIS) study, aged 65-84 years, underwent comprehensive clinical and neuropsychological examinations, and brain MRI at the baseline assessment. The subjects meeting the SIVD imaging criteria (n = 89) were compared to the other subjects of the sample (n = 524). RESULTS: SIVD was associated with lower education, hypertension and, independently, with obesity. The subjects with SIVD had more often motor impairment, a history of falls, and subtle impairment in activities of daily living, but they did not differ for depressive symptoms. SIVD subjects performed significantly inferiorly in tests of global cognitive function, psychomotor speed, attention and executive functions, verbal fluency, and working memory. CONCLUSION: In this population of nondisabled older adults with WML, SIVD was related to specific clinical and functional characteristics. Neuropsychological features included psychomotor slowing as well as deficits in attention and executive functions.
Authors:
Hanna Jokinen; Hely Kalska; Raija Ylikoski; Sofia Madureira; Ana Verdelho; Alida Gouw; Philip Scheltens; Frederik Barkhof; Marieke C Visser; Franz Fazekas; Reinhold Schmidt; John O'Brien; Michael Hennerici; Hansjorg Baezner; Gunhild Waldemar; Anders Wallin; Hugues Chabriat; Leonardo Pantoni; Domenico Inzitari; Timo Erkinjuntti;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2009-02-14
Journal Detail:
Title:  Cerebrovascular diseases (Basel, Switzerland)     Volume:  27     ISSN:  1421-9786     ISO Abbreviation:  Cerebrovasc. Dis.     Publication Date:  2009  
Date Detail:
Created Date:  2009-04-02     Completed Date:  2009-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100851     Medline TA:  Cerebrovasc Dis     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  336-44     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Affiliation:
Department of Psychology, University of Helsinki, Helsinki, Finland. hanna.jokinen@helsinki.fi
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MeSH Terms
Descriptor/Qualifier:
Activities of Daily Living
Aged
Aged, 80 and over
Brain / pathology*
Cognition
Dementia, Vascular / diagnosis,  pathology*,  psychology*
Disability Evaluation
Educational Status
Europe
Female
Humans
Hypertension
Longitudinal Studies
Magnetic Resonance Imaging*
Male
Neuropsychological Tests*
Obesity
Psychomotor Performance
Investigator
Investigator/Affiliation:
Timo Erkinjuntti / ; Tarja Pohjasvaara / ; Pia Pihanen / ; Raija Ylikoski / ; Hanna Jokinen / ; Meija-Marjut Somerkoski / ; Riitta Mäntylä / ; Oili Salonen / ; Franz Fazekas / ; Reinhold Schmidt / ; Stefan Ropele / ; Brigitte Rous / ; Katja Petrovic / ; Ulrike Garmehi / ; Alexandra Seewann / ; José M Ferro / ; Ana Verdelho / ; Sofia Madureira / ; Carla Moleiro / ; Philip Scheltens / ; Ilse van Straaten / ; Frederik Barkhof / ; Alida Gouw / ; Wiesje van der Flier / ; Anders Wallin / ; Michael Jonsson / ; Karin Lind / ; Arto Nordlund / ; Sindre Rolstad / ; Ingela Isblad / ; Lars-Olof Wahlund / ; Milita Crisby / ; Anna Pettersson / ; Kaarina Amberla / ; Hugues Chabriat / ; Karen Hernandez / ; Annie Kurtz / ; Dominique Hervé / ; Sarah Benisty / ; Jean Pierre Guichard / ; Michael Hennerici / ; Christian Blahak / ; Hansjorg Baezner / ; Martin Wiarda / ; Susanne Seip / ; Gunhild Waldemar / ; Egill Rostrup / ; Charlotte Ryberg / ; Tim Dyrby / ; Olaf B Paulson / ; Ellen Garde / ; John O'Brien / ; Sanjeet Pakrasi / ; Mani Krishnan / ; Andrew Teodorczuk / ; Michael Firbank / ; Philip English / ; Thais Minett / ; Domenico Inzitari / ; Luciano Bartolini / ; Anna Maria Basile / ; Eliana Magnani / ; Monica Martini / ; Mario Mascalchi / ; Marco Moretti / ; Leonardo Pantoni / ; Anna Poggesi / ; Giovanni Pracucci / ; Emilia Salvadori / ; Michela Simoni / ; Domenico Inzitari / ; Timo Erkinjuntti / ; Philip Scheltens / ; Marieke Visser / ; Peter Langhorne / ; Kjell Asplund /

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