| MRI contrast using solid-state, B1-distorting, microelectromechanical systems (MEMS) microresonant devices (MRDs). | |
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MedLine Citation:
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PMID: 19189289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Presently, signal generation in MRI depends on the concentration and relaxivity of protons or other MR-active nuclei, and contrast depends on local differences in signal. In this proof-of-principle study, we explore the use of nonchemical, solid-state devices for generating detectable signal and/or contrast in vitro and in vivo. We introduce the concept of microresonant devices (MRDs), which are micron-sized resonators fabricated using microelectromechanical systems (MEMS) technology. Fifteen-micrometer (15-microm)-thick, coil MRDs were designed to resonate at the 3T Larmor frequency of protons (127.7 MHz) and were fabricated using tantalum (Ta) oxide thin-film capacitors and copper-plated spiral inductors. The performance of MRDs having final diameters of 300, 500, and 1000 microm were characterized in saline using a radio frequency (RF) scanning microscope and a clinical 3T MR scanner. The measured B(1) fields of 300 microm to 1000 microm MRDs ranged from 3.25 microT to 3.98 microT, and their quality factors (Q) ranged from 3.9 to 7.2. When implanted subcutaneously in the flank of a mouse, only MRDs tuned to the resonant frequency of protons generated a measurable in vivo B(1) field. This study lays the foundation for a new class of solid-state contrast agents for MRI. |
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Authors:
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Razvan Ciocan; Robert E Lenkinski; Jonathan Bernstein; Mirela Bancu; Robert Marquis; Alex Ivanishev; Fotini Kourtelidis; Aya Matsui; Jeffrey Borenstein; John V Frangioni |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 61 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-31 Completed Date: 2009-06-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 860-6 Citation Subset: IM |
Affiliation:
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Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Contrast Media Equipment Design Equipment Failure Analysis Image Enhancement / instrumentation* Magnetic Resonance Imaging / instrumentation* Mice Micro-Electrical-Mechanical Systems / instrumentation* Reproducibility of Results Semiconductors Sensitivity and Specificity Transducers* Vibration |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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